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Bambang Pharmaceutical Depot Inc.

Ceftazidime (Zeftacare) 1g Powder for Injection I.M/I.V Vial 1's

Ceftazidime (Zeftacare) 1g Powder for Injection I.M/I.V Vial 1's

Regular price ₱96.00
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Here's a detailed overview of Ceftazidime (Zeftacare) 1g Powder for Injection I.M/I.V Vial 1's:


Product Description

Ceftazidime (Zeftacare) 1g Powder for Injection I.M/I.V Vial is a broad-spectrum antibiotic belonging to the cephalosporin class. It is used for the treatment of various bacterial infections, particularly those caused by gram-negative bacteria. The medication is provided in the form of a powder that, when reconstituted, can be administered via intramuscular (I.M.) or intravenous (I.V.) injection. Ceftazidime is effective in treating infections such as respiratory tract infections, urinary tract infections, skin infections, and sepsis caused by susceptible organisms.

  • Formulation: Each vial contains 1g of Ceftazidime (as Ceftazidime sodium) in powder form, which must be reconstituted before injection.

  • Packaging: The product is available in a 1 vial pack.

  • Mechanism of Action: Ceftazidime works by inhibiting bacterial cell wall synthesis, leading to the destruction of bacteria. It is highly effective against gram-negative bacteria such as Pseudomonas aeruginosa and some gram-positive bacteria.


Indications

Ceftazidime (Zeftacare) 1g Powder for Injection is indicated for the treatment of infections caused by susceptible microorganisms. The most common indications include:

  1. Respiratory Tract Infections:

    • Community-acquired pneumonia (CAP)

    • Hospital-acquired pneumonia (HAP)

    • Acute exacerbations of chronic obstructive pulmonary disease (COPD)

  2. Urinary Tract Infections (UTIs):

    • Pyelonephritis

    • Cystitis

    • Urosepsis

  3. Skin and Soft Tissue Infections:

    • Cellulitis

    • Abscesses

    • Wound infections

  4. Intra-abdominal Infections:

    • Peritonitis

    • Bacterial infections after abdominal surgeries

  5. Bone and Joint Infections:

    • Osteomyelitis

    • Septic arthritis

  6. Sepsis:

    • Ceftazidime is often used as part of the treatment for sepsis caused by susceptible organisms.

  7. Meningitis (in combination with other antibiotics) due to its ability to cross the blood-brain barrier.


Dosages

The dosage of Ceftazidime (Zeftacare) 1g Powder for Injection will depend on the type and severity of the infection, as well as the patient's age, renal function, and overall health. Below are general dosage guidelines:

  • Adults:

    • Typical dose: 1-2g every 8-12 hours via intravenous or intramuscular injection, depending on the severity of the infection.

    • For severe infections: 2g every 8 hours may be used.

    • Sepsis and serious infections: Higher doses (up to 3g every 8 hours) may be administered under close medical supervision.

  • Pediatric Patients (under 12 years):

    • Typical dose: 30-50 mg/kg body weight per day, divided into 2-3 doses, depending on the severity of the infection.

  • Renal Impairment:

    • Dosage adjustments may be necessary for patients with impaired renal function. In cases of severe renal impairment (creatinine clearance < 30 mL/min), the dosing interval may be extended.

Reconstitution: Ceftazidime should be reconstituted with sterile water or saline according to the instructions on the vial. After reconstitution, it should be administered immediately or stored in the refrigerator and used within a certain time frame (as directed on the label).

Note: Always follow the specific dosing instructions provided by the healthcare provider.


Side Effects

While Ceftazidime (Zeftacare) 1g Powder for Injection is generally well-tolerated, some patients may experience side effects. Common and less common side effects include:

  • Common Side Effects:

    • Injection site reactions: Pain, redness, swelling, or irritation at the site of injection.

    • Gastrointestinal issues: Nausea, vomiting, diarrhea, or abdominal pain.

    • Rash or skin reactions: Mild skin rash or itching.

    • Fever: Some patients may develop a mild fever.

  • Less Common Side Effects:

    • Changes in blood counts: A decrease in white blood cells (leukopenia), red blood cells (anemia), or platelets (thrombocytopenia).

    • Elevated liver enzymes: Indicating liver dysfunction.

    • Allergic reactions: Itching, swelling, or hives (urticaria). Rare cases of anaphylaxis (severe allergic reaction) may occur.

    • Renal dysfunction: Changes in kidney function, including elevated creatinine levels or renal failure (particularly in patients with pre-existing kidney issues).

  • Serious Side Effects (requires immediate medical attention):

    • Severe allergic reactions: Difficulty breathing, swelling of the face, lips, or throat, which could be signs of anaphylaxis.

    • Severe diarrhea: Diarrhea associated with Clostridium difficile infection, which may be severe and require specific treatment.

    • Severe skin reactions: Such as Stevens-Johnson syndrome or toxic epidermal necrolysis (rare).

If you experience any of these serious side effects, seek medical attention immediately.


Contraindications

Ceftazidime (Zeftacare) 1g Powder for Injection should be avoided or used with caution in the following circumstances:

  1. Hypersensitivity (Allergy):

    • Do not use if you are allergic to Ceftazidime, any other cephalosporin antibiotics, or any component of the formulation.

    • Individuals with a history of severe allergic reactions (e.g., anaphylaxis) to penicillins or cephalosporins should use Ceftazidime with caution or avoid it entirely.

  2. Severe Renal Impairment:

    • Ceftazidime is primarily eliminated by the kidneys, and patients with severe kidney dysfunction may require dose adjustments or an alternative medication.

  3. Neonates (newborns):

    • The use of Ceftazidime in neonates, especially in high doses, may require careful monitoring due to immature renal function and potential risks of toxicity.

  4. History of Colitis:

    • Caution is advised in patients with a history of colitis (inflammation of the colon), particularly antibiotic-associated Clostridium difficile colitis.

  5. Pregnancy and Breastfeeding:

    • Pregnancy: Ceftazidime is classified as Category B by the FDA, meaning that it is generally considered safe during pregnancy, but it should only be used if absolutely necessary and under the guidance of a healthcare provider.

    • Breastfeeding: Ceftazidime is excreted in breast milk, but it is generally considered safe for use during breastfeeding. Consult a healthcare provider for further guidance.


Precautions

  • Renal Function Monitoring: Patients with renal impairment should be closely monitored, and dosage adjustments may be required.

  • Superinfection: Prolonged use of Ceftazidime may result in overgrowth of non-susceptible organisms, including fungi. It is important to monitor for signs of superinfection during treatment.

  • Injection Site Reactions: To minimize discomfort, ensure proper technique when administering the injection and rotate sites if needed.

  • Drug Interactions: Ceftazidime may interact with other drugs, including loop diuretics (which may increase the risk of nephrotoxicity) and other antibiotics. Inform your healthcare provider of all medications you are taking.


Storage

  • Storage Instructions: Store Ceftazidime (Zeftacare) 1g Powder for Injection at room temperature in a cool, dry place, away from direct sunlight. Once reconstituted, the solution should be used immediately or stored in the refrigerator and used within the recommended time frame (as indicated on the product label).

  • Keep Out of Reach of Children: Store the medication in a secure place to prevent accidental ingestion.


Conclusion

Ceftazidime (Zeftacare) 1g Powder for Injection is a potent antibiotic used to treat a variety of infections caused by susceptible bacteria, especially gram-negative bacteria. It is administered via I.M. or I.V. injection and is effective for serious infections such as pneumonia, urinary tract infections, skin infections, and sepsis.

While it is generally well-tolerated, like all antibiotics, it can cause side effects and should be used with caution in certain populations. It is important to follow the prescribed dosage and consult your healthcare provider if you experience any adverse reactions or if you have any pre-existing medical conditions.

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