Cefuroxime Axetil (Cefusaph 250) 250mg/5ml Powder for Oral Suspension 60ml

Cefuroxime Axetil (Cefusaph 250) 250mg/5ml Powder for Oral Suspension 60ml

Product Description:

Cefusaph 250 is an oral suspension that contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic. It is presented as a powder that is reconstituted with water to form a suspension, making it easy for patients, especially children, to take. Each 5ml of the reconstituted suspension contains 250mg of Cefuroxime Axetil.

Cefuroxime Axetil is a broad-spectrum antibiotic used to treat a variety of bacterial infections. It works by inhibiting the synthesis of bacterial cell walls, ultimately causing the bacteria to break down and die.

Indications:

Cefusaph 250mg/5ml is used to treat a wide range of bacterial infections, including but not limited to:

1. Upper Respiratory Tract Infections:

   • Sinusitis: Infection of the sinuses.

   • Pharyngitis/Tonsillitis: Inflammation of the throat or tonsils.

   • Otitis Media: Middle ear infections.

2. Lower Respiratory Tract Infections:

   • Bronchitis: Inflammation of the bronchial tubes.

   • Pneumonia: Infection of the lungs.

3. Urinary Tract Infections (UTIs):

   • Such as cystitis (bladder infection) and pyelonephritis (kidney infection).

4. Skin and Soft Tissue Infections:

   • Including cellulitis and infected wounds.

5. Gonorrhea:

   • Cefuroxime is also effective against gonococcal infections.

6. Lyme Disease:

   • Cefuroxime is used for the treatment of early-stage Lyme disease, a bacterial infection transmitted by ticks.

Dosage and Administration:

Cefusaph 250mg/5ml should be taken as directed by a healthcare provider. The dosage may vary depending on the severity of the infection and the patient's age and weight.

General Dosage Guidelines:

• Adults and children over 12 years:

  • 250mg to 500mg twice daily, depending on the severity of the infection.

• Children (5-12 years):

  • 250mg twice daily, or as recommended by the healthcare provider.

• Children (2-5 years):

  • 125mg to 250mg twice daily, as directed by a doctor.

• Infants (under 2 years):

  • The dosage will be determined based on body weight. It is typically 125mg to 250mg twice daily.

The dosage should be adjusted for patients with renal impairment. It is important to follow the prescribed instructions, and the suspension should be shaken well before use.

Side Effects:

Common side effects may include:

1. Gastrointestinal Issues:

   • Diarrhea

   • Nausea or Vomiting

   • Abdominal pain or discomfort

2. Allergic Reactions:

   • Rash or hives

   • Itching

   • Swelling of the face, tongue, or throat (which may indicate a serious allergic reaction).

3. Hematologic Effects:

   • Eosinophilia (an increase in a type of white blood cell).

   • Leukopenia (low white blood cell count).

   • Thrombocytopenia (low platelet count).

4. Liver and Kidney Effects:

   • Elevated liver enzymes (as detected in blood tests).

   • Changes in kidney function (especially in patients with pre-existing kidney issues).

5. Other Less Common Effects:

   • Headache.

   • Dizziness.

   • Fatigue.

Contraindications:

Cefusaph 250mg/5ml is contraindicated in the following cases:

1. Hypersensitivity:

   • Contraindicated in patients with a known allergy to Cefuroxime, cephalosporins, or any component of the formulation.

   • Cross-sensitivity may occur in patients allergic to penicillins.

2. Severe Renal Impairment:

   • In patients with severely impaired kidney function, a dose adjustment may be required, and the drug should be used with caution.

3. History of Clostridium Difficile Infection:

   • As with other antibiotics, Cefuroxime may alter normal gut flora and promote the overgrowth of Clostridium difficile, leading to pseudomembranous colitis (a potentially severe intestinal condition).

4. Pregnancy:

   • Cefuroxime is categorized as Pregnancy Category B, meaning it is generally considered safe during pregnancy. However, it should be used during pregnancy only when clearly needed and under the guidance of a healthcare provider.

5. Breastfeeding:

   • Cefuroxime passes into breast milk in small amounts, and while it is generally considered safe, it should be used with caution in breastfeeding mothers.

Precautions and Warnings:

• Allergic Reactions: Caution is advised in patients with a history of severe allergic reactions to other antibiotics, particularly penicillins. Anaphylaxis and other severe allergic reactions, although rare, have been reported with cephalosporin antibiotics.

• Renal Impairment: For patients with mild to moderate renal dysfunction, the dose may need to be adjusted. In patients with severe renal impairment, Cefuroxime should be used with extreme caution.

• Superinfection: Prolonged use of antibiotics may lead to the development of superinfections, including fungal infections or infections caused by antibiotic-resistant organisms. Monitoring for signs of superinfection is essential.

• Diarrhea: Cefuroxime may cause diarrhea, which can be a sign of Clostridium difficile infection. If severe diarrhea occurs, consult a doctor immediately.

Conclusion:

Cefusaph 250mg/5ml Powder for Oral Suspension is a potent antibiotic used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, and Lyme disease. Its easy-to-administer suspension form makes it ideal for children or those who have difficulty swallowing tablets. While generally well-tolerated, it is important to follow dosage instructions carefully and monitor for potential side effects, particularly allergic reactions or gastrointestinal disturbances. Always consult with a healthcare provider before starting or adjusting the dosage of this medication, especially for individuals with kidney or liver concerns.