Co Amoxiclav (Comxicla 250) 312.5mg per 5ml Powder for Suspension 60ml

Antibacterial
(Penicillin + Beta- Lactamase Inhibitor)

Certainly! Here is a detailed breakdown of Co-Amoxiclav (Comxicla 250) 312.5mg per 5ml Powder for Suspension 60ml:

Product Description:

Co-Amoxiclav (Comxicla 250) 312.5mg per 5ml Powder for Suspension 60ml is a combination antibiotic medication containing Amoxicillin and Clavulanic Acid. Amoxicillin is a broad-spectrum penicillin-type antibiotic that works by killing bacteria. Clavulanic Acid is a beta-lactamase inhibitor that helps prevent bacteria from breaking down amoxicillin, thereby extending the effectiveness of the antibiotic.

Each 5 mL of the suspension contains 250 mg of Amoxicillin and 62.5 mg of Clavulanic Acid, and the total volume is 60 mL.

This medication is available in powder form, which, when reconstituted with water, forms an oral suspension that is easy to administer to both children and adults.

Indications:

Co-Amoxiclav (Comxicla 250) is indicated for the treatment of a variety of bacterial infections caused by susceptible organisms. These include:

1. Respiratory Tract Infections:

   • Acute otitis media (middle ear infection)

   • Sinusitis

   • Pharyngitis and tonsillitis

   • Acute exacerbations of chronic bronchitis

   • Pneumonia

2. Urinary Tract Infections:

   • Cystitis (bladder infection)

   • Pyelonephritis (kidney infection)

3. Skin and Soft Tissue Infections:

   • Cellulitis

   • Abscesses

   • Wounds or bites

4. Dental Infections:

   • Periodontal abscesses

5. Intra-abdominal Infections:

   • Peritonitis

   • Infected biliary tract infections

6. Prophylaxis:

   • Preoperative prophylaxis in certain surgical procedures to prevent infections.

This combination is particularly useful for infections caused by beta-lactamase-producing bacteria, which are resistant to certain penicillins but sensitive to the combination of amoxicillin and clavulanic acid.

Dosages:

The dosage of Co-Amoxiclav (Comxicla 250) depends on the type of infection, the patient's age, and the severity of the infection.

For Adults and Children Over 12 Years:

• The typical dose is 10 mL (625 mg), which contains 500 mg of Amoxicillin and 125 mg of Clavulanic Acid, taken every 12 hours for 7-10 days.

• In severe infections, the dose may be increased according to the doctor's recommendation.

For Children (under 12 years):

• Children under 3 months: The dosage is typically based on body weight and adjusted according to the severity of the infection. It is important to consult a pediatrician for accurate dosing.

• Children 3 months to 12 years:

  • Mild to moderate infections: 5 mL (312.5 mg) every 12 hours.

  • Severe infections: The dose may be adjusted based on the child’s weight and the infection’s severity.

For Children (Age 3-6 months):

• The recommended dose is 2.5 mL (156.25 mg) every 12 hours.

For Renal Impairment:

• In patients with impaired renal function, the dosage should be adjusted based on the degree of renal insufficiency.

It is important to complete the full course of therapy even if symptoms improve to avoid bacterial resistance.

Side Effects:

Like all medications, Co-Amoxiclav (Comxicla 250) can cause side effects. Not everyone will experience them, but some common and serious side effects include:

Common Side Effects:

• Gastrointestinal disturbances:

  • Diarrhea

  • Nausea or vomiting

  • Abdominal pain

  • Indigestion

• Skin reactions:

  • Rash or itching

Serious Side Effects:

• Severe allergic reactions (anaphylaxis), which can include:

  • Swelling of the face, lips, or throat

  • Difficulty breathing

  • Hives

• Liver damage: Symptoms include yellowing of the skin or eyes (jaundice), dark urine, and upper right abdominal pain.

• Blood disorders:

  • Thrombocytopenia (low platelet count), leading to easy bruising or bleeding.

  • Leukopenia (low white blood cell count), which increases the risk of infections.

• Clostridium difficile-associated diarrhea (CDAD): A potentially serious infection of the colon that can occur with antibiotic use, characterized by severe diarrhea, abdominal cramps, and fever.

• Severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis (rare, but life-threatening conditions).

If any of these serious side effects occur, discontinue use and seek medical help immediately.

Contraindications:

Co-Amoxiclav (Comxicla 250) should not be used in the following situations:

1. Hypersensitivity (allergy) to Amoxicillin, Clavulanic Acid, or any other component of the formulation.

2. History of severe allergic reactions (e.g., anaphylaxis) to penicillins, cephalosporins, or other beta-lactam antibiotics.

3. Liver dysfunction:

   • Co-Amoxiclav should not be used in patients with severe liver disease or a history of cholestatic jaundice or liver dysfunction associated with previous use of Amoxicillin/Clavulanic Acid combinations.

4. Mononucleosis (infectious mononucleosis):

   • Patients with this condition may be at higher risk of developing a rash when treated with Amoxicillin or Amoxicillin/Clavulanic Acid combinations.

Precautions:

• Renal impairment: In patients with renal dysfunction, the dosage may need to be adjusted to prevent accumulation of the drug.

• Pregnancy: Co-Amoxiclav is generally considered safe during pregnancy (Category B), but should only be used when absolutely necessary and prescribed by a healthcare provider.

• Breastfeeding: Amoxicillin and Clavulanic Acid are excreted into breast milk in small amounts. The use of this medication during breastfeeding should be monitored by a doctor, as it may cause mild gastrointestinal upset in the infant.

Important Notes:

• Full Course: It is important to complete the entire prescribed course, even if symptoms improve. Stopping the medication prematurely can lead to the infection returning or contribute to antibiotic resistance.

• Missed Dose: If you miss a dose of Co-Amoxiclav (Comxicla 250), take it as soon as you remember. If it’s nearly time for the next dose, skip the missed dose—do not take two doses at once.

• Hydration: Drink plenty of fluids, especially if you experience diarrhea, to help prevent dehydration.

Conclusion:

Co-Amoxiclav (Comxicla 250) 312.5mg per 5ml Powder for Suspension 60ml is a broad-spectrum antibiotic combination used to treat a wide range of bacterial infections, including respiratory, urinary, skin, and intra-abdominal infections. It combines Amoxicillin, a penicillin-class antibiotic, with Clavulanic Acid, which extends the effectiveness of Amoxicillin against resistant bacteria. While generally well-tolerated, it may cause gastrointestinal disturbances, skin reactions, or, more rarely, serious allergic or liver reactions. Always follow the prescribed dosage, complete the full course, and consult a healthcare provider if any serious side effects occur.