Colchicine (Goutsaph) 500mcg Anti-Gout Tablet 100's

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Product Description:

Colchicine (Goutsaph) 500mcg Anti-Gout Tablet is a medication primarily used for the management of gout attacks and for the prevention of recurrent gout episodes. The active ingredient in this tablet, Colchicine, works by reducing inflammation and pain associated with gout, a form of arthritis caused by the accumulation of uric acid crystals in the joints.

Indications:

Colchicine (Goutsaph) is indicated for the following conditions:

• Acute Gout Attacks: It is used to treat sudden, painful flare-ups of gout by reducing inflammation.

• Prevention of Gout Flares: It helps to prevent future gout attacks in patients who experience recurrent gout.

• Familial Mediterranean Fever (FMF): In some cases, colchicine is used to manage and reduce the frequency of attacks in patients with FMF.

• Chronic Gout: It may also be used as part of long-term treatment for gout, particularly in patients who cannot tolerate other medications or for those with frequent attacks.

Dosage:

The usual dosage for Colchicine (Goutsaph) 500mcg Anti-Gout Tablet depends on the severity of the condition:

• For Acute Gout Flare-ups:

  • Initial dose: 1 tablet (500mcg) at the first sign of a gout attack, followed by an additional tablet after 1 hour if needed.

  • The maximum dosage should not exceed 3 tablets (1.5 mg) within the first hour.

  • After initial dosing, treatment is usually continued with 500mcg to 1mg every 1 to 2 hours until symptoms improve or until the maximum recommended daily dose is reached.

• For Chronic Gout Prevention:

  • Typically, 500mcg to 1mg daily, divided into 1 or 2 doses.

  • The dose can be adjusted based on the patient's response and tolerance.

Side Effects:

Common side effects may include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, abdominal pain, and cramping.

• Hematologic Effects: Rarely, colchicine may cause blood-related side effects such as low white blood cell count (leukopenia), low platelet count (thrombocytopenia), and anemia.

• Muscle-related Issues: Muscle pain or weakness (myopathy) may occur, especially with long-term use.

• Liver Effects: Liver toxicity is rare but can happen, particularly when colchicine is combined with other medications that affect liver function.

• Neurological Symptoms: Headache, dizziness, or tingling sensations.

Severe side effects (less common) include:

• Toxicity, particularly in patients with renal or hepatic dysfunction.

• Rhabdomyolysis (muscle breakdown), especially if colchicine is taken in high doses or with certain medications.

Contraindications:

Colchicine (Goutsaph) should not be used in the following situations:

• Hypersensitivity to Colchicine or any other component of the tablet.

• Severe Renal Impairment (Kidney Failure): Colchicine is contraindicated in patients with severe kidney dysfunction due to increased risk of toxicity.

• Severe Hepatic Impairment (Liver Failure): Use of colchicine is contraindicated in patients with severe liver dysfunction.

• Pregnancy and Breastfeeding: Colchicine should only be used during pregnancy if the potential benefits outweigh the risks. It is generally advised against during breastfeeding.

• Concurrent Use with Certain Medications: It should not be used with drugs that inhibit the enzyme CYP3A4 (such as certain antibiotics, antifungals, and antivirals), or those that affect the liver and kidney function as these increase the risk of colchicine toxicity.

Precautions:

• Renal and Hepatic Function: Colchicine should be used with caution in patients with mild to moderate renal or hepatic impairment, and the dosage may need to be adjusted accordingly.

• Drug Interactions: Colchicine can interact with various drugs, such as statins, cyclosporine, and other medications that affect the metabolism in the liver. Always inform your healthcare provider of all medications you are taking.

This information should provide a comprehensive overview of Colchicine (Goutsaph) 500mcg Anti-Gout Tablet. If you need further details, consult with a healthcare professional or pharmacist for tailored advice.