Helps to lower blood pressure, thereby reducing the risk of strokes, heart attacks, and kidney problems.
Heart Failure:
Used to treat symptomatic heart failure, improving survival rates and reducing the need for hospitalization.
Left Ventricular Dysfunction:
Prescribed for patients with asymptomatic left ventricular dysfunction to prevent the development of symptomatic heart failure and reduce the risk of hospitalization.
Diabetic Nephropathy:
Helps to protect the kidneys in patients with diabetes and hypertension, slowing down the progression of kidney disease.
Uses:
Mechanism of Action:
Enalapril is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This results in the dilation of blood vessels, which lowers blood pressure and decreases the workload on the heart.
Dosage and Administration:
The typical starting dose and adjustments are based on the condition being treated:
Hypertension: Starting dose is usually 5 mg once daily, which can be adjusted based on the patient's response, up to 40 mg per day in divided doses.
Heart Failure: Initial dose is generally 2.5 mg once daily, gradually increased to the target dose of 20 mg per day in divided doses.
Asymptomatic Left Ventricular Dysfunction: Initial dose is usually 2.5 mg twice daily, with a maintenance dose of 20 mg per day in divided doses.
Diabetic Nephropathy: Dosage similar to that used for hypertension, adjusted based on kidney function and blood pressure response.
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