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Bambang Pharmaceutical Depot Inc.

Epinephrine (Epix) 1mg/ml Solution for Injection I.M/I.V/S.C 1ml x Ampoule 10's

Epinephrine (Epix) 1mg/ml Solution for Injection I.M/I.V/S.C 1ml x Ampoule 10's

Regular price ₱432.00
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Here’s a detailed overview of Epinephrine (Epix) 1mg/ml Solution for Injection (IM/IV/SC) 1ml x Ampoule 10's:


Product Description:

Epinephrine (Epix) 1mg/ml is a solution for injection containing epinephrine (adrenaline), a potent sympathomimetic drug. It is available in 1ml ampoules, with each ampoule containing 1mg of epinephrine per ml. Epinephrine is a naturally occurring hormone and neurotransmitter, primarily produced by the adrenal glands. It plays a critical role in the body’s fight-or-flight response, causing a range of physiological effects including increased heart rate, improved blood flow to muscles, and dilation of the airways.

This formulation is used in emergency medical situations, especially in life-threatening conditions such as severe allergic reactions (anaphylaxis) or cardiac arrest.


Indications:

Epinephrine (Epix) 1mg/ml Solution for Injection is primarily used in emergency settings for the following conditions:

  1. Anaphylaxis:

    • Epinephrine is the first-line treatment for severe allergic reactions or anaphylaxis, which may be caused by insect stings, food allergies, or drug reactions. It rapidly reverses the life-threatening symptoms such as airway constriction and hypotension.

  2. Cardiac Arrest:

    • Epinephrine is used in cardiopulmonary resuscitation (CPR) for the treatment of cardiac arrest, improving heart function and increasing the chances of restoring a normal heart rhythm.

  3. Severe Asthma Attacks:

    • Epinephrine may be administered in patients experiencing severe asthma attacks that are unresponsive to other bronchodilators.

  4. Hypotension:

    • In cases of severe hypotension or shock, epinephrine can be used to increase blood pressure and improve circulation.

  5. Croup in Children:

    • In children, epinephrine is sometimes used in the treatment of croup, a condition that causes airway swelling and difficulty breathing.


Dosages and Administration:

Epinephrine (Epix) 1mg/ml Solution for Injection is administered intramuscularly (IM), intravenously (IV), or subcutaneously (SC), depending on the clinical situation. The following are general dosage guidelines:

For Anaphylaxis:

  • Adults:

    • 0.3–0.5 mg administered IM or SC every 5-10 minutes as needed, depending on the severity of the reaction.

  • Children:

    • 0.01 mg/kg body weight up to a maximum dose of 0.3 mg administered IM or SC every 5-10 minutes if required.

For Cardiac Arrest:

  • Adults:

    • 1 mg IV every 3-5 minutes during cardiac arrest until return of spontaneous circulation or advanced cardiac life support is provided.

For Severe Asthma or Bronchospasm:

  • Adults and Children:

    • 0.3–0.5 mg IM as a one-time dose, repeatable every 20 minutes if necessary.

For Hypotension or Shock:

  • Adults:

    • IV infusion of 0.1-0.5 mcg/kg/min to restore blood pressure, titrating based on clinical response.


Side Effects:

Epinephrine is generally well tolerated when used as directed, but it may cause several side effects, especially if overused or improperly administered. Common side effects include:

Common Side Effects:

  • Increased heart rate (tachycardia)

  • Elevated blood pressure (hypertension)

  • Anxiety or restlessness

  • Tremors or shaking

  • Headache

  • Dizziness

  • Nausea and vomiting

Serious Side Effects (Seek immediate medical attention if these occur):

  • Severe chest pain (angina) or heart attack symptoms (especially in patients with pre-existing heart disease)

  • Arrhythmias (irregular heartbeat)

  • Pulmonary edema (fluid in the lungs)

  • Severe allergic reactions (though rare, epinephrine can sometimes induce an allergic reaction in sensitive individuals)

  • Severe hypertension leading to stroke or organ damage


Contraindications:

Epinephrine should not be used in certain conditions or should be used with extreme caution. The following are contraindications and conditions requiring caution:

  1. Hypersensitivity to Epinephrine:

    • Contraindicated in patients who are known to have an allergy or hypersensitivity to epinephrine.

  2. Narrow-Angle Glaucoma:

    • Epinephrine should not be used in individuals with narrow-angle glaucoma, as it may increase intraocular pressure.

  3. Shock due to non-anaphylactic causes:

    • Epinephrine should be used with caution in patients with non-anaphylactic shock, as it may worsen the condition.

  4. Severe Hypertension:

    • Caution should be exercised in patients with severe hypertension, as epinephrine may further elevate blood pressure.

  5. Coronary Artery Disease:

    • Patients with coronary artery disease, heart rhythm disorders, or myocardial ischemia should use epinephrine only under strict medical supervision, as it may worsen these conditions.

  6. Hyperthyroidism:

    • Epinephrine should be used with caution in patients with hyperthyroidism, as it can exacerbate symptoms like tachycardia or arrhythmias.

  7. Pregnancy:

    • Epinephrine is a Category C drug during pregnancy, meaning it may pose risks to the fetus. It should only be used if the potential benefits outweigh the risks, especially in life-threatening situations like anaphylaxis.

  8. Pheochromocytoma:

    • Epinephrine should be used with extreme caution in patients with pheochromocytoma, a tumor of the adrenal glands, as it may trigger a hypertensive crisis.


Precautions:

  • Monitoring:

    • Close monitoring of vital signs, including heart rate and blood pressure, is essential during administration of epinephrine, particularly during IV infusion or repeated injections.

  • Proper Injection Technique:

    • Epinephrine should be administered by a healthcare professional trained in emergency techniques to minimize the risk of complications, such as incorrect dosing or improper injection technique.

  • Drug Interactions:

    • Epinephrine may interact with other medications, including beta-blockers, which may counteract its effects. Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) may also increase the hypertensive effects of epinephrine.


Summary:

Epinephrine (Epix) 1mg/ml Solution for Injection is a critical emergency medication used primarily in the treatment of anaphylaxis, cardiac arrest, severe asthma attacks, and hypotension. It works by stimulating alpha- and beta-adrenergic receptors to produce life-saving physiological effects such as bronchodilation, vasoconstriction, and increased heart rate.

  • Dosage: 1mg IM/IV/SC for anaphylaxis or cardiac arrest, with repeat doses as necessary.

  • Side Effects: Tachycardia, hypertension, anxiety, headache, arrhythmias.

  • Contraindications: Hypersensitivity, narrow-angle glaucoma, non-anaphylactic shock, severe hypertension, coronary artery disease, hyperthyroidism, pregnancy.

Always administer epinephrine in a controlled, clinical setting, and monitor for potential side effects or complications. Consult a healthcare provider before using epinephrine, especially in patients with underlying heart disease or other chronic conditions.

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