Bambang Pharmaceutical Depot Inc.
Epinephrine (Epix) 1mg/ml Solution for Injection I.M/I.V/S.C 1ml x Ampoule 10's
Epinephrine (Epix) 1mg/ml Solution for Injection I.M/I.V/S.C 1ml x Ampoule 10's
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Here’s a detailed overview of Epinephrine (Epix) 1mg/ml Solution for Injection (IM/IV/SC) 1ml x Ampoule 10's:
Product Description:
Epinephrine (Epix) 1mg/ml is a solution for injection containing epinephrine (adrenaline), a potent sympathomimetic drug. It is available in 1ml ampoules, with each ampoule containing 1mg of epinephrine per ml. Epinephrine is a naturally occurring hormone and neurotransmitter, primarily produced by the adrenal glands. It plays a critical role in the body’s fight-or-flight response, causing a range of physiological effects including increased heart rate, improved blood flow to muscles, and dilation of the airways.
This formulation is used in emergency medical situations, especially in life-threatening conditions such as severe allergic reactions (anaphylaxis) or cardiac arrest.
Indications:
Epinephrine (Epix) 1mg/ml Solution for Injection is primarily used in emergency settings for the following conditions:
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Anaphylaxis:
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Epinephrine is the first-line treatment for severe allergic reactions or anaphylaxis, which may be caused by insect stings, food allergies, or drug reactions. It rapidly reverses the life-threatening symptoms such as airway constriction and hypotension.
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Cardiac Arrest:
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Epinephrine is used in cardiopulmonary resuscitation (CPR) for the treatment of cardiac arrest, improving heart function and increasing the chances of restoring a normal heart rhythm.
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Severe Asthma Attacks:
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Epinephrine may be administered in patients experiencing severe asthma attacks that are unresponsive to other bronchodilators.
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Hypotension:
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In cases of severe hypotension or shock, epinephrine can be used to increase blood pressure and improve circulation.
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Croup in Children:
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In children, epinephrine is sometimes used in the treatment of croup, a condition that causes airway swelling and difficulty breathing.
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Dosages and Administration:
Epinephrine (Epix) 1mg/ml Solution for Injection is administered intramuscularly (IM), intravenously (IV), or subcutaneously (SC), depending on the clinical situation. The following are general dosage guidelines:
For Anaphylaxis:
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Adults:
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0.3–0.5 mg administered IM or SC every 5-10 minutes as needed, depending on the severity of the reaction.
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Children:
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0.01 mg/kg body weight up to a maximum dose of 0.3 mg administered IM or SC every 5-10 minutes if required.
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For Cardiac Arrest:
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Adults:
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1 mg IV every 3-5 minutes during cardiac arrest until return of spontaneous circulation or advanced cardiac life support is provided.
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For Severe Asthma or Bronchospasm:
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Adults and Children:
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0.3–0.5 mg IM as a one-time dose, repeatable every 20 minutes if necessary.
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For Hypotension or Shock:
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Adults:
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IV infusion of 0.1-0.5 mcg/kg/min to restore blood pressure, titrating based on clinical response.
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Side Effects:
Epinephrine is generally well tolerated when used as directed, but it may cause several side effects, especially if overused or improperly administered. Common side effects include:
Common Side Effects:
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Increased heart rate (tachycardia)
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Elevated blood pressure (hypertension)
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Anxiety or restlessness
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Tremors or shaking
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Headache
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Dizziness
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Nausea and vomiting
Serious Side Effects (Seek immediate medical attention if these occur):
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Severe chest pain (angina) or heart attack symptoms (especially in patients with pre-existing heart disease)
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Arrhythmias (irregular heartbeat)
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Pulmonary edema (fluid in the lungs)
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Severe allergic reactions (though rare, epinephrine can sometimes induce an allergic reaction in sensitive individuals)
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Severe hypertension leading to stroke or organ damage
Contraindications:
Epinephrine should not be used in certain conditions or should be used with extreme caution. The following are contraindications and conditions requiring caution:
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Hypersensitivity to Epinephrine:
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Contraindicated in patients who are known to have an allergy or hypersensitivity to epinephrine.
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Narrow-Angle Glaucoma:
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Epinephrine should not be used in individuals with narrow-angle glaucoma, as it may increase intraocular pressure.
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Shock due to non-anaphylactic causes:
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Epinephrine should be used with caution in patients with non-anaphylactic shock, as it may worsen the condition.
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Severe Hypertension:
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Caution should be exercised in patients with severe hypertension, as epinephrine may further elevate blood pressure.
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Coronary Artery Disease:
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Patients with coronary artery disease, heart rhythm disorders, or myocardial ischemia should use epinephrine only under strict medical supervision, as it may worsen these conditions.
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Hyperthyroidism:
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Epinephrine should be used with caution in patients with hyperthyroidism, as it can exacerbate symptoms like tachycardia or arrhythmias.
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Pregnancy:
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Epinephrine is a Category C drug during pregnancy, meaning it may pose risks to the fetus. It should only be used if the potential benefits outweigh the risks, especially in life-threatening situations like anaphylaxis.
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Pheochromocytoma:
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Epinephrine should be used with extreme caution in patients with pheochromocytoma, a tumor of the adrenal glands, as it may trigger a hypertensive crisis.
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Precautions:
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Monitoring:
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Close monitoring of vital signs, including heart rate and blood pressure, is essential during administration of epinephrine, particularly during IV infusion or repeated injections.
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Proper Injection Technique:
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Epinephrine should be administered by a healthcare professional trained in emergency techniques to minimize the risk of complications, such as incorrect dosing or improper injection technique.
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Drug Interactions:
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Epinephrine may interact with other medications, including beta-blockers, which may counteract its effects. Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) may also increase the hypertensive effects of epinephrine.
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Summary:
Epinephrine (Epix) 1mg/ml Solution for Injection is a critical emergency medication used primarily in the treatment of anaphylaxis, cardiac arrest, severe asthma attacks, and hypotension. It works by stimulating alpha- and beta-adrenergic receptors to produce life-saving physiological effects such as bronchodilation, vasoconstriction, and increased heart rate.
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Dosage: 1mg IM/IV/SC for anaphylaxis or cardiac arrest, with repeat doses as necessary.
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Side Effects: Tachycardia, hypertension, anxiety, headache, arrhythmias.
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Contraindications: Hypersensitivity, narrow-angle glaucoma, non-anaphylactic shock, severe hypertension, coronary artery disease, hyperthyroidism, pregnancy.
Always administer epinephrine in a controlled, clinical setting, and monitor for potential side effects or complications. Consult a healthcare provider before using epinephrine, especially in patients with underlying heart disease or other chronic conditions.
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