Hydrocortisone (Hyzonate) 500mg Powder for Injection (IMIV) Vial 1's

Generic Name: Hydrocortisone

Brand Name: Hyzonate

Strength: 500mg

Form: Vial

Manufacturer:

Imported and Distributed by:

Classification: Corticosteroid

Indication/Uses: 

Hydrocortisone (Hyzonate) 500mg Powder for Injection (IM/IV) Vial is used for its anti-inflammatory and immunosuppressive properties. Here are the indications and uses:

Indications and Uses

1. Anti-Inflammatory Treatment:

   • Severe Inflammatory Conditions: Used in the management of severe inflammatory conditions such as acute adrenal insufficiency, severe allergies, and certain autoimmune diseases.
   • Exacerbations of Chronic Conditions: Can be used to treat exacerbations of chronic conditions like rheumatoid arthritis or lupus when other treatments are not effective.

2. Immunosuppressive Therapy:

   • Organ Transplantation: May be used as part of immunosuppressive therapy to prevent organ rejection following transplantation.
   • Autoimmune Disorders: Helps control symptoms of autoimmune disorders by suppressing abnormal immune responses.

3. Shock and Severe Allergic Reactions:

   • Shock: Used in cases of shock due to severe infection or other causes to stabilize the patient.
   • Severe Allergic Reactions: Effective in treating severe allergic reactions and anaphylaxis.

Mechanism of Action

• Glucocorticoid: Hydrocortisone is a corticosteroid that mimics the effects of cortisol, a natural hormone produced by the adrenal glands. It works by suppressing inflammation, reducing immune system activity, and stabilizing various cellular processes.

Dosage and Administration

• Dosage:

  • Adults: The dosage varies depending on the condition being treated and the patient's response. A common dosage range is 100-500mg administered IM or IV, with frequency adjusted based on clinical response and condition severity.
  • Children: Dosage for children is typically based on weight and specific condition. Consult a healthcare provider for appropriate dosing.

• Administration:

  • Intramuscular (IM): Administer the reconstituted solution into a large muscle, such as the gluteus or thigh muscle.
  • Intravenous (IV): Administer the reconstituted solution directly into the vein. The injection is typically given slowly over several minutes.

Instructions for Use

1. Reconstitution:

   • Reconstitute the powder with the appropriate diluent provided or as directed by the manufacturer. Ensure the solution is clear and free from particles before administration.

2. Injection:

   • Follow proper aseptic techniques to avoid contamination. Use sterile equipment for reconstitution and injection.

3. Regular Use:

   • Adhere to the prescribed dosage and frequency. Monitor the patient for signs of improvement or adverse effects.

4. Missed Dose:

   • For scheduled injections, administer as soon as possible. If it is close to the next scheduled dose, skip the missed dose and continue with the regular schedule. Do not double up on doses.

Precautions

• Allergic Reactions: Ensure there are no known allergies to hydrocortisone or other corticosteroids.
• Infections: Use with caution in patients with active infections, as corticosteroids can suppress immune response.
• Chronic Conditions: Monitor for potential side effects, especially with long-term use, such as osteoporosis, diabetes, or hypertension.
• Pregnancy and Breastfeeding: Consult a healthcare provider before using during pregnancy or breastfeeding.

Side Effects

• Common: Increased appetite, weight gain, fluid retention, or mood changes.
• Serious: Potential for more severe effects with long-term use, including increased risk of infections, high blood sugar, or adrenal suppression. Seek medical attention if severe side effects occur.

Storage

• Storage: Store the powder in a cool, dry place. Reconstituted solutions should be used immediately or as directed by the manufacturer.

Hydrocortisone (Hyzonate) 500mg Powder for Injection is effective for treating severe inflammation and managing various acute conditions. Following dosage instructions and monitoring for side effects are essential for optimal treatment outcomes.