Isoxsuprine HCI (Duvadrine) 5mg/ml (10mg/2ml) Solution for Injection (I.V Infusion/I.M)

Here’s the detailed information for Isoxsuprine HCl (Duvadrine) 5mg/ml (10mg/2ml) Solution for Injection (IV Infusion/IM):

Product Description:

Isoxsuprine HCl (Duvadrine) is a vasodilator medication available as a 5mg/ml solution for injection in 10mg/2ml ampoules. It is designed to be administered intravenously (IV) or intramuscularly (IM). The medication works by relaxing the smooth muscles in the blood vessels, thereby improving blood flow and reducing the risk of complications associated with poor circulation.

Indications:

Isoxsuprine HCl (Duvadrine) is primarily used for conditions related to poor blood circulation, including:

1. Peripheral Vascular Diseases (PVD):

   • Raynaud's disease (a condition where blood vessels in the fingers and toes constrict, leading to color changes and numbness).

   • Chronic arterial insufficiency (reduced blood flow to the limbs due to narrowed arteries).

   • Intermittent claudication (pain and cramping in the legs due to inadequate blood supply, typically triggered by physical activity).

   • Varicose veins and other conditions associated with vascular insufficiency.

2. Obstetric Use:

   • Isoxsuprine is sometimes used for its tocolytic properties, helping to relax the uterine muscles to prevent premature labor or contractions.

Dosage and Administration:

The dosage of Isoxsuprine HCl (Duvadrine) varies based on the specific condition being treated, the patient’s health status, and the route of administration (IV or IM).

For Peripheral Vascular Diseases:

• Intramuscular (IM) or Intravenous (IV) Injection:

  • Typical starting dose: 5-10mg (1-2 ml) administered 2-3 times a day.

  • The dose may be adjusted based on the patient's clinical response.

For Obstetric Use (Tocolytic Therapy):

• Initial Dose: Administer 5-10mg (1-2 ml) intravenously or intramuscularly, followed by maintenance doses of 5-10mg every 4-6 hours as needed.

• Adjust dosage as per the physician's recommendation based on the progression of labor and uterine activity.

Side Effects:

Like all medications, Isoxsuprine HCl (Duvadrine) can cause side effects, although not everyone experiences them. Common and serious side effects may include:

Common Side Effects:

• Headache: A common side effect due to vasodilation.

• Dizziness or lightheadedness: Especially when standing up quickly.

• Nausea.

• Flushing (skin redness).

• Tachycardia (fast heart rate) due to vasodilation and reflex response.

Serious Side Effects:

• Hypotension (low blood pressure): Due to the vasodilation effect, which may lead to dizziness or fainting.

• Palpitations or irregular heartbeats: An increased heart rate can be a side effect.

• Severe allergic reactions: Includes symptoms like rash, itching, swelling of the face or throat, and difficulty breathing (anaphylaxis).

• Chest pain (rare).

Contraindications:

Isoxsuprine HCl (Duvadrine) should not be used in the following situations:

1. Hypersensitivity:

   • Contraindicated in patients with a known allergy or hypersensitivity to Isoxsuprine or any other component of the formulation.

2. Severe Heart Conditions:

   • Should not be used in patients with severe coronary artery disease, arrhythmias, or other serious heart conditions, as it may worsen these conditions due to its effect on heart rate and blood pressure.

3. Severe Hypotension:

   • Should not be administered to patients with low blood pressure (hypotension), as it may further decrease blood pressure.

4. Preterm Labor (when contraindicated):

   • Should be avoided when contraindicated in conditions where tocolytic treatment may not be appropriate, such as certain complications of pregnancy.

5. Breastfeeding:

   • Not recommended during breastfeeding unless the potential benefits outweigh the risks, as the safety of Isoxsuprine during lactation has not been fully established.

Precautions:

1. Cardiovascular Monitoring:

   • Caution is required in patients with heart disease or high blood pressure, as Isoxsuprine may affect heart rate and blood pressure.

2. Electrolyte Imbalance:

   • It should be used with caution in patients with an electrolyte imbalance, as it may exacerbate underlying conditions.

3. Pregnancy:

   • Use during pregnancy should be limited to situations where the benefit to the mother outweighs the risk to the fetus, especially in cases of preterm labor. Always consult a healthcare provider before use.

4. Renal or Hepatic Impairment:

   • Patients with liver or kidney dysfunction should be monitored closely when receiving this medication.

5. Monitor for Side Effects:

   • Close monitoring of blood pressure is important, particularly in elderly patients or those with a history of cardiovascular conditions.

Summary:

Isoxsuprine HCl (Duvadrine) is a vasodilator used to treat conditions such as peripheral vascular diseases and preterm labor. The typical dosage for IV/IM use is 5-10mg (1-2 ml) every 2-3 times a day, depending on the patient's response and condition. Side effects can include headache, dizziness, flushing, and tachycardia. It should be avoided in patients with hypotension, severe heart conditions, or those who are allergic to the drug.

As with all medications, it is essential to use Isoxsuprine under the supervision of a healthcare provider, especially for its use in treating preterm labor, where careful monitoring is necessary.