Metronidazole (Erzol) 5mg/ml 500mgx100ml Solution for I.V. Infusion 100ml

Generic Name: Metronidazole

Brand Name: Erzol

Strength: 5mg / ml 500mg x 100ml

Form: Vial

Manufacturer:

Imported and Distributed by:

Classification: Nitroimidazole Derivative

Indication/Uses:

Metronidazole (Erzol) 5mg/ml (500mg/100ml) Solution for I.V. Infusion 100ml is used to treat a variety of infections caused by anaerobic bacteria and certain protozoa. Here are the primary indications and uses for this intravenous (IV) form of metronidazole:

Indications and Uses

1. Anaerobic Bacterial Infections:

   • Intra-abdominal Infections: Effective for treating infections such as peritonitis, intra-abdominal abscesses, and postoperative wound infections caused by anaerobic bacteria.
   • Pelvic Infections: Used to treat pelvic inflammatory disease, endometritis, and other gynecological infections.
   • Sepsis: Part of the treatment regimen for septicemia caused by anaerobic bacteria.
   • Bone and Joint Infections: Used for osteomyelitis and other bone and joint infections caused by anaerobic bacteria.
   • Central Nervous System Infections: Effective for brain abscesses and other CNS infections caused by anaerobic bacteria.
   • Respiratory Tract Infections: Used to treat anaerobic pleuropulmonary infections, including pneumonia and lung abscesses.

2. Protozoal Infections:

   • Amoebiasis: Used to treat severe cases of amoebic dysentery and liver abscesses caused by Entamoeba histolytica.
   • Giardiasis: Used for the treatment of Giardia lamblia infections.

3. Bacterial Vaginosis:

   • Severe Cases: For treating severe bacterial vaginosis caused by Gardnerella vaginalis and other anaerobic bacteria, especially when oral administration is not possible.

4. Surgical Prophylaxis:

   • Prevention of Postoperative Infections: Administered before surgery to prevent postoperative infections caused by anaerobic bacteria, particularly in colorectal surgery, gynecologic surgery, and other procedures with a high risk of anaerobic contamination.

Dosage and Administration

• Dosage: The typical adult dose is 500 mg (one 100 ml vial) infused intravenously over 30-60 minutes every 8 hours. The exact dosage and frequency depend on the type and severity of the infection being treated.
• Administration: The solution is administered intravenously, and the infusion should be given slowly to reduce the risk of adverse effects. It is essential to follow the healthcare provider's instructions for preparation and administration.

Precautions

• Liver Function: Use with caution in patients with severe hepatic impairment, as metronidazole is primarily metabolized by the liver. Dosage adjustments may be necessary.
• Alcohol Consumption: Patients should avoid alcohol during treatment and for at least 48 hours after the last dose to prevent a disulfiram-like reaction (nausea, vomiting, flushing).
• Central Nervous System: Caution is advised in patients with central nervous system disorders due to the potential for neurological side effects, including seizures and peripheral neuropathy.

Side Effects

• Common: Side effects may include nausea, headache, dizziness, and a metallic taste in the mouth.
• Serious: Serious side effects are rare but can include seizures, encephalopathy, peripheral neuropathy, and severe allergic reactions. Any signs of these serious side effects should be reported to a healthcare provider immediately.

Monitoring

• Effectiveness: Monitor the patient's response to treatment, ensuring that infection symptoms are resolving.
• Adverse Effects: Regular monitoring for signs of serious adverse effects, particularly neurological symptoms, is essential. Liver function tests may be necessary for patients on prolonged therapy.

Metronidazole (Erzol) 5mg/ml (500mg/100ml) Solution for I.V. Infusion 100ml is used for treating severe anaerobic bacterial and protozoal infections, as well as for surgical prophylaxis to prevent postoperative infections. Proper administration, dosing, and monitoring are crucial to ensure the effectiveness and safety of the treatment.