Metronidazole (Metronova IV) 5mg/ml 500mg/100ml Solution for I.V. Infusion 100'ml

Generic Name: Metronidazole

Brand Name: Metronova IV

Strength: 5mg / ml 500mg / 100ml

Form: Vial

Manufacturer:

Imported and Distributed by:

Classification: Antiprotozoal

Indication/Uses:

Metronidazole (Metronova IV) 5mg/ml (500mg/100ml) Solution for I.V. Infusion 100ml is used for the treatment of a variety of serious infections caused by anaerobic bacteria and certain protozoa. Here are the primary indications and uses for this intravenous (IV) form of metronidazole:

Indications and Uses

1. Anaerobic Bacterial Infections:

   • Intra-abdominal Infections: Treats peritonitis, intra-abdominal abscesses, and postoperative infections caused by anaerobic bacteria.
   • Pelvic Infections: Effective for pelvic inflammatory disease, endometritis, and other gynecological infections.
   • Sepsis: Used in the treatment of septicemia caused by anaerobic bacteria.
   • Bone and Joint Infections: Treats osteomyelitis and other bone and joint infections caused by anaerobic bacteria.
   • Central Nervous System Infections: Effective for brain abscesses and other CNS infections caused by anaerobic bacteria.
   • Respiratory Tract Infections: Used for anaerobic pleuropulmonary infections, including pneumonia and lung abscesses.

2. Protozoal Infections:

   • Amoebiasis: Used for severe amoebic dysentery and liver abscesses caused by Entamoeba histolytica.
   • Giardiasis: Treats Giardia lamblia infections.

3. Bacterial Vaginosis:

   • Severe Cases: Treats severe bacterial vaginosis caused by Gardnerella vaginalis and other anaerobic bacteria, especially when oral administration is not possible.

4. Surgical Prophylaxis:

   • Prevention of Postoperative Infections: Administered preoperatively to prevent postoperative infections caused by anaerobic bacteria, particularly in colorectal, gynecologic, and other surgeries with high anaerobic infection risk.

Dosage and Administration

• Dosage: The typical adult dose is 500 mg (one 100 ml vial) infused intravenously over 30-60 minutes every 8 hours. Dosage may vary based on the severity and type of infection.
• Administration: Administered intravenously, the infusion should be slow to minimize adverse effects. Follow healthcare provider instructions for preparation and administration.

Precautions

• Liver Function: Caution in patients with severe hepatic impairment; dose adjustment may be required as metronidazole is metabolized by the liver.
• Alcohol Consumption: Avoid alcohol during treatment and for at least 48 hours after the last dose to prevent disulfiram-like reactions (nausea, vomiting, flushing).
• Central Nervous System: Use with caution in patients with central nervous system disorders due to potential neurological side effects, such as seizures and peripheral neuropathy.

Side Effects

• Common: Nausea, headache, dizziness, and a metallic taste in the mouth.
• Serious: Rare but serious side effects include seizures, encephalopathy, peripheral neuropathy, and severe allergic reactions. Report any signs of serious side effects to a healthcare provider immediately.

Monitoring

• Effectiveness: Monitor the patient's response to treatment, ensuring infection symptoms are resolving.
• Adverse Effects: Regularly check for signs of serious adverse effects, especially neurological symptoms. Liver function tests may be necessary for prolonged therapy.

Metronidazole (Metronova IV) 5mg/ml (500mg/100ml) Solution for I.V. Infusion 100ml is used to treat severe anaerobic bacterial and protozoal infections, and for surgical prophylaxis to prevent postoperative infections. Proper administration, dosing, and monitoring are essential to ensure the treatment's effectiveness and safety.