Omeprazole (Giozole) 40mg I.V infusion 1 Vial+ 10ml

Generic Name: Omeprazole

Brand Name: Giozole

Strength: 40mg

Form: Vial

Manufacturer:

Imported and Distributed by:

Classification: Proton Pump Inhibitor

Indication/Uses:

Omeprazole (Giozole) 40mg I.V. Infusion is a medication used primarily for the treatment of gastrointestinal conditions. Here are the primary indications and uses for this formulation:

Indications and Uses

1. Gastroesophageal Reflux Disease (GERD):

   • Severe GERD: Omeprazole IV is used for patients with severe GERD, especially when oral administration is not possible or effective. It helps to reduce stomach acid, relieve symptoms, and promote healing of the esophagus.

2. Peptic Ulcer Disease:

   • Treatment of Ulcers: Used for the treatment of peptic ulcers, including gastric and duodenal ulcers. It helps to reduce stomach acid, promoting ulcer healing and providing symptom relief.

3. Zollinger-Ellison Syndrome:

   • Management: Omeprazole IV is used to manage Zollinger-Ellison syndrome, a condition characterized by excessive gastric acid production. It helps control acid secretion and manage symptoms associated with this syndrome.

4. Prevention of Stress Ulcers:

   • Critical Care: In critically ill patients, omeprazole IV may be used to prevent stress-induced mucosal disease and reduce the risk of stress ulcers.

5. Post-Surgical Management:

   • Gastrointestinal Surgery: It can be used in the postoperative setting to manage and prevent acid-related complications following gastrointestinal surgery.

Mechanism of Action

• Proton Pump Inhibitor (PPI): Omeprazole works by inhibiting the proton pump in the parietal cells of the stomach lining. This action reduces the production of gastric acid, leading to a decrease in stomach acidity and providing relief from acid-related symptoms and conditions.

Dosage and Administration

• Typical Dosage:
  • GERD: 40 mg IV infusion once daily, adjusted based on clinical response.
  • Peptic Ulcer Disease: 40 mg IV infusion once daily, with adjustments as needed.
  • Zollinger-Ellison Syndrome: The dosage may vary depending on the severity of the condition and the patient's response to treatment.
  • Prevention of Stress Ulcers: Dosage is determined based on the patient’s risk factors and clinical condition.
• Administration: The vial of omeprazole is diluted and administered via intravenous infusion. The infusion is typically administered over 30 minutes to 2 hours, depending on the specific protocol and patient condition.

Precautions

• Renal and Hepatic Function: Use with caution in patients with renal or hepatic impairment, as omeprazole is metabolized in the liver.
• Drug Interactions: Omeprazole may interact with other medications, including certain anticoagulants and antifungal agents. Inform your healthcare provider of all medications you are taking.

Side Effects

• Common: Headache, nausea, vomiting, and diarrhea.
• Less Common: Rash, dizziness, and abdominal pain. Prolonged use may also lead to potential risks such as Clostridium difficile infection and bone fractures.

Monitoring

• Effectiveness: Monitor the patient’s response to treatment, including symptom relief and any potential reduction in acid-related complications.
• Side Effects: Regularly assess for any adverse effects and adjust treatment as necessary.

Omeprazole (Giozole) 40mg I.V. Infusion is used to manage severe gastrointestinal conditions, such as GERD, peptic ulcers, Zollinger-Ellison syndrome, and stress ulcer prevention. Proper administration, dosage adjustments, and monitoring for side effects are essential for effective treatment and patient safety.