Phenylpropanolamine Hydrochloride Chlorphenamine Maleate Paracetamol (Symdex) 6.25mg/500mcg/125mg per 5ml Syrup 60ml

6.25mg/500mcg/125mg per 5ml Syrup

DECONGESTANT / ANTIHISTAMINE / ANALGESIC / ANTIPYRETIC

Here’s a detailed overview of Phenylpropanolamine Hydrochloride, Chlorphenamine Maleate, and Paracetamol (Symdex) 6.25mg/500mcg/125mg per 5ml Syrup 60ml:

Product Description:

Symdex Syrup is a combination oral formulation containing Phenylpropanolamine Hydrochloride (6.25mg), Chlorphenamine Maleate (500mcg), and Paracetamol (125mg) per 5 ml. It is used to relieve symptoms associated with common colds, flu-like symptoms, and allergic rhinitis.

• Phenylpropanolamine is a sympathomimetic that works as a decongestant, helping to relieve nasal congestion by narrowing blood vessels in the nasal passages.

• Chlorphenamine Maleate is an antihistamine that helps reduce allergic symptoms, such as sneezing, itchy eyes, and runny nose, by blocking histamine.

• Paracetamol (also called acetaminophen) is an analgesic and antipyretic, which helps to relieve pain and fever.

This 60ml syrup is designed for convenient oral administration, providing effective relief from cold, allergy, and flu symptoms in both adults and children when used as directed.

Indications:

Symdex Syrup is indicated for the treatment and relief of symptoms associated with:

• Common cold and flu-like symptoms, including fever, headaches, body aches, and sore throat.

• Allergic rhinitis (seasonal or perennial allergies), such as hay fever, with symptoms like sneezing, itchy eyes, and runny nose.

• Sinus congestion and nasal stuffiness caused by upper respiratory infections.

• Mild to moderate pain (such as headaches or muscle pain) and fever (due to its Paracetamol content).

Dosage:

The dosage of Symdex Syrup depends on the patient’s age and condition. Always follow the instructions provided by your healthcare provider or the label on the bottle.

For Adults and Children Over 12 Years:

• Recommended dose: 10 ml (equivalent to 12.5mg of Phenylpropanolamine, 1mg of Chlorphenamine Maleate, and 250mg of Paracetamol) every 4-6 hours as needed.

• Maximum dose: Do not exceed 40 ml (equivalent to 50mg of Phenylpropanolamine, 4mg of Chlorphenamine Maleate, and 1g of Paracetamol) in 24 hours.

For Children 6-12 Years:

• Recommended dose: 5 ml (equivalent to 6.25mg of Phenylpropanolamine, 500mcg of Chlorphenamine Maleate, and 125mg of Paracetamol) every 4-6 hours.

• Maximum dose: Do not exceed 20 ml in 24 hours.

For Children 2-6 Years:

• Recommended dose: 2.5 ml (equivalent to 3.125mg of Phenylpropanolamine, 250mcg of Chlorphenamine Maleate, and 62.5mg of Paracetamol) every 4-6 hours.

• Maximum dose: Do not exceed 10 ml in 24 hours.

Note: For children under 2 years, the use of Symdex Syrup should only be under the guidance of a healthcare provider. Always use the provided measuring spoon or dropper to ensure the correct dose is administered.

Side Effects:

While Symdex Syrup is effective in relieving symptoms, side effects may occur. These side effects can vary depending on the individual and the dosage used.

Common Side Effects:

• Drowsiness, dizziness, or sedation (due to Chlorphenamine Maleate, an antihistamine).

• Dry mouth, throat irritation, or nasal dryness.

• Gastrointestinal discomfort: nausea, vomiting, or upset stomach (especially if taken on an empty stomach).

• Restlessness or insomnia (due to Phenylpropanolamine's stimulant effects).

Serious Side Effects:

• Severe allergic reactions (e.g., rash, swelling of the face or throat, difficulty breathing). These can occur due to Chlorphenamine Maleate or any other ingredient.

• Elevated blood pressure: Phenylpropanolamine can cause an increase in blood pressure, particularly with high doses or prolonged use.

• Liver damage: Symptoms like yellowing of the skin or eyes (jaundice) may occur due to an overdose or prolonged high doses of Paracetamol.

• Severe drowsiness or confusion, particularly in the elderly or in those who combine this syrup with alcohol or other sedatives.

• Severe dizziness, fainting, or an abnormal heart rate, especially with excessive use or in patients with pre-existing heart conditions.

If any of these side effects occur, discontinue use immediately and seek medical attention.

Contraindications:

Symdex Syrup is contraindicated in the following situations:

• Hypersensitivity to Phenylpropanolamine, Chlorphenamine Maleate, Paracetamol, or any of the other ingredients in the syrup.

• Severe hypertension or heart disease: Phenylpropanolamine can elevate blood pressure and should be avoided in individuals with uncontrolled hypertension or heart conditions.

• Hyperthyroidism: Patients with thyroid disorders should avoid Symdex because Phenylpropanolamine may worsen symptoms of hyperthyroidism.

• Glaucoma: This syrup contains Chlorphenamine Maleate, an antihistamine, which can increase intraocular pressure and should be avoided in patients with glaucoma.

• Severe liver disease: Paracetamol is metabolized by the liver, and in patients with severe liver impairment, its use could result in liver toxicity or failure.

• Severe renal disease: If kidney function is severely impaired, the drug should be used with caution or avoided due to the risk of toxicity from Paracetamol.

Pregnancy and Breastfeeding:

• Pregnancy: Symdex Syrup should be used during pregnancy only if deemed absolutely necessary by a healthcare provider. Some of its ingredients (particularly Phenylpropanolamine and Chlorphenamine Maleate) should be used with caution during pregnancy.

• Breastfeeding: Chlorphenamine Maleate and Phenylpropanolamine can pass into breast milk, potentially causing drowsiness or other adverse effects in the infant. Paracetamol is generally considered safe during breastfeeding, but Symdex Syrup should only be used under medical supervision.

Precautions:

• Alcohol: Avoid alcohol while using Symdex Syrup, as it may increase the sedative effects of Chlorphenamine Maleate and Phenylpropanolamine, leading to increased drowsiness or dizziness.

• Other medications: Consult your doctor if you are taking other decongestants, antihistamines, or antidepressants, as Symdex Syrup may interact with these medications.

• Chronic conditions: Use with caution in patients with diabetes, prostate problems, heart disease, glaucoma, or thyroid disorders.

• Driving and operating machinery: The sedative effect of Chlorphenamine Maleate may impair your ability to drive or operate machinery. Exercise caution until you know how this medication affects you.

• Overuse: Do not exceed the recommended dose, as high doses of Paracetamol can lead to liver damage, and excessive use of Phenylpropanolamine can lead to elevated blood pressure and other cardiovascular effects.

Note: Symdex Syrup should be used only as directed. If symptoms persist or worsen, or if you experience any serious side effects, consult a healthcare provider immediately. Always ensure you are measuring the syrup accurately using the provided dropper or dosing device.