Sevelamer Carbonate 800mg Film Coated Tablet 100's

Generic Name: SEVELAMER CARBONATE

Brand Name: SEVERQO

Strength: 800mg

Form: FILM COATED TABLET

Manufacturer: PHAROSE REMEDIES LIMITED

Imported by: MEDETHIX
Distributed by: ELLEBASY MEDICALE GROUP INC.

Classification: DRUG FOR TREATMENT OF HYPERKALEMIA AND HYPERPHOSPHATEMIA

Indication/Uses: 

1. Hyperphosphatemia in Chronic Kidney Disease (CKD)

   • Usage: Sevelamer Carbonate is primarily indicated for the control of hyperphosphatemia (high phosphate levels) in patients with CKD on dialysis (hemodialysis or peritoneal dialysis).
   • Importance: Elevated phosphate levels in CKD patients can lead to severe complications, including bone disease (renal osteodystrophy), cardiovascular disease, and calcification of tissues and organs.

2. Prevention of Secondary Hyperparathyroidism

   • Usage: By controlling serum phosphate levels, Sevelamer Carbonate helps reduce the risk of secondary hyperparathyroidism, a condition where the parathyroid glands produce too much parathyroid hormone (PTH) due to chronic high phosphate levels.
   • Importance: Proper management of phosphate levels can help prevent complications associated with secondary hyperparathyroidism, such as bone pain and fractures.

Uses

1. Phosphate Binding

   • Mechanism: Sevelamer Carbonate works by binding to dietary phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream. This helps lower serum phosphate levels.
   • Administration: It is usually taken three times a day with meals to effectively bind dietary phosphate.

2. Reduction of Serum Phosphate Levels

   • Clinical Benefit: Effective in reducing serum phosphate levels in patients on dialysis, contributing to the overall management of CKD-related complications.
   • Outcome: Improved phosphate control helps mitigate the risk of vascular calcification and cardiovascular events, common in CKD patients.

3. Improvement in Quality of Life

   • Patient Benefit: By maintaining proper phosphate levels, patients can experience improved quality of life, with fewer symptoms related to high phosphate levels and associated complications.

Dosage and Administration

• Initial Dose: Typically, the starting dose is 800 to 1600 mg three times a day with meals.
• Titration: The dose may be adjusted based on serum phosphate levels, aiming to maintain target phosphate levels as advised by healthcare providers.