Bambang Pharmaceutical Depot Inc.
Silver Sulfadiazine (Mazine) 10mg/g Cream Antibacterial 20g
Silver Sulfadiazine (Mazine) 10mg/g Cream Antibacterial 20g
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100mg/g Cream
ANTIBACTERIAL
Here's the detailed information for Silver Sulfadiazine (Mazine) 10mg/g Cream Antibacterial 20g:
Product Description:
Silver Sulfadiazine (Mazine) 10mg/g Cream is an antibacterial topical medication used primarily for the prevention and treatment of infections in burns. The cream contains Silver Sulfadiazine, a combination of silver, known for its antimicrobial properties, and sulfadiazine, a sulfonamide antibiotic. The cream form makes it easy to apply directly to the skin, especially for patients with burns, wounds, or skin grafts.
The silver in this formulation helps kill a broad range of bacteria and fungi, which is particularly useful in the care of burn wounds or open skin wounds, where the risk of infection is high. Silver Sulfadiazine (Mazine) is typically used in hospital settings, although it can be prescribed for home use in some cases, under the guidance of a healthcare provider.
Indications:
Silver Sulfadiazine (Mazine) Cream is primarily used for:
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Prevention of Infection in Burns:
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For second- and third-degree burns, where there is a significant risk of bacterial infection.
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Treatment of Skin Infections:
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To prevent and treat bacterial infections in open wounds, abrasions, and cuts.
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Skin Graft Care:
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Silver Sulfadiazine is also used to help prevent infection in skin grafts and donor sites.
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Chronic Wound Management:
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Used in some cases for chronic wounds that are at risk of infection, especially diabetic ulcers or pressure sores.
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Dosage and Administration:
Silver Sulfadiazine (Mazine) Cream is for topical use only. The following general dosage and administration guidelines apply:
For Burns and Wounds:
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Apply a thin layer (about 1-2 mm thick) of the cream to the affected area once or twice a day.
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Gently rub the cream into the wound and cover the treated area with a sterile bandage or dressing if required.
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Continue the treatment until the wound has healed, or as directed by your healthcare provider.
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Change the dressing and reapply the cream regularly (usually once or twice daily).
For Skin Infections:
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Apply a thin layer of the cream to the affected skin areas once or twice daily, depending on the severity of the infection.
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Use as directed by your healthcare provider.
Side Effects:
While Silver Sulfadiazine (Mazine) is generally well-tolerated, some people may experience side effects. Common and serious side effects are listed below:
Common Side Effects:
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Skin irritation or rash at the site of application.
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Burning or stinging sensation upon application (usually temporary).
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Itching or redness at the application site.
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Dry skin or peeling of the skin.
Serious Side Effects (Seek medical attention immediately):
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Severe allergic reactions: Symptoms may include swelling of the face, lips, throat, or tongue, difficulty breathing, or severe rash.
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Skin blistering or open sores: Unusual or severe reactions at the site of application.
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Methemoglobinemia (a condition where the blood cannot carry oxygen properly): Symptoms include shortness of breath, cyanosis (blue skin), and fatigue.
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Blood disorders: Rare cases of leukopenia (reduced white blood cells) or thrombocytopenia (reduced platelets), which can increase the risk of infections or bleeding.
Overdose:
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Topical overdose is unlikely, but excessive application over large areas or on broken skin may increase the risk of side effects. If too much cream is used, consult a healthcare provider.
Contraindications:
Silver Sulfadiazine (Mazine) Cream should not be used in the following situations:
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Hypersensitivity to Silver Sulfadiazine or Other Components:
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Individuals who are allergic to Silver Sulfadiazine, sulfadiazine, or any other ingredients in the cream should not use this product.
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Severe Renal Impairment:
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Silver Sulfadiazine should be used with caution in individuals with severe kidney disease or renal impairment as it is eliminated via the kidneys. Dosage adjustments may be necessary, and regular monitoring may be required.
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Pregnancy:
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Silver Sulfadiazine (Mazine) should be used during pregnancy only if clearly needed and prescribed by a healthcare provider. Animal studies have shown possible risks, so use it with caution in pregnant women, especially during the first trimester.
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Newborns and Infants:
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Silver Sulfadiazine should not be used in newborns or infants younger than 2 months of age, as they may be more vulnerable to the side effects of the medication.
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G6PD Deficiency:
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Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency should avoid using Silver Sulfadiazine, as it can lead to the development of hemolytic anemia in such patients.
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Precautions:
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Monitor for Allergic Reactions:
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Patients should be monitored for signs of allergic reactions after the first few applications of the cream. If any severe reactions (such as difficulty breathing or swelling of the face) occur, the medication should be discontinued immediately.
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Renal and Hepatic Function:
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Silver Sulfadiazine should be used with caution in patients with renal (kidney) or hepatic (liver) impairments. Adjustments to the dose or frequency of application may be necessary.
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Infection Monitoring:
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Regular monitoring of the wound site should be performed to ensure that the infection is controlled. If signs of infection persist or worsen, a healthcare provider should be consulted to assess the need for alternative treatments.
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Prolonged Use:
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Prolonged or excessive use of Silver Sulfadiazine on large wounds or open skin areas can increase the risk of systemic absorption and potential side effects, such as methemoglobinemia or blood dyscrasias.
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Avoid Contact with Eyes:
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The cream should not be applied near the eyes. If the cream accidentally comes into contact with the eyes, rinse immediately with water. If irritation persists, seek medical advice.
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Summary:
Silver Sulfadiazine (Mazine) 10mg/g Cream is an antibacterial topical treatment used for the prevention and treatment of infections in burns, wounds, and skin grafts. The cream works by combining the antimicrobial action of silver with the antibacterial effects of sulfadiazine. It helps to prevent and control infection while promoting healing of the affected skin.
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Indications: Primarily used for burns, wound care, and skin grafts to prevent or treat infection.
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Dosage: Apply a thin layer to the affected area once or twice daily as directed.
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Side Effects: Can include skin irritation, stinging, and rarely, serious allergic reactions or blood disorders.
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Contraindications: Avoid use if allergic to silver sulfadiazine, severe kidney disease, pregnancy (especially during the first trimester), and newborns or infants under 2 months.
Always follow the instructions from your healthcare provider when using Silver Sulfadiazine (Mazine), especially in cases involving severe burns or wounds, and monitor for potential side effects or signs of infection.
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