Silver Sulfadiazine (Retasildex) 10mg/g (1% w/w) Topical Cream Antibacterial Sulfonamide 1 Tube 20g

Generic Name: Silver Sulfadiazine

Brand Name: Retasildex

Strength: 10mg/g (1% w/w)

Form: Cream

Manufacturer:

Imported and Distributed by:

Classification: Antibacterial

Indication/Uses:

Silver Sulfadiazine, marketed as Retasildex, is a topical antibacterial cream containing 10mg/g (1% w/w) of silver sulfadiazine. It is primarily used for the prevention and treatment of infections in burns and other skin conditions. Here are the main indications and uses:

1. Burn Wounds:

   • Prevention and Treatment of Infection: Used to prevent and treat bacterial infections in second- and third-degree burns. Silver sulfadiazine helps to control bacterial growth and reduce the risk of infection in the burn area.

2. Skin Ulcers and Pressure Sores:

   • Treatment of Infected Ulcers: Applied to infected skin ulcers and pressure sores to promote healing and prevent the spread of infection.

3. Minor Cuts and Abrasions:

   • Prevention of Infection: Can be used to prevent infection in minor cuts, abrasions, and other superficial skin wounds.

Mechanism of Action:

• Silver: Silver ions have broad-spectrum antimicrobial activity. They disrupt bacterial cell walls and interfere with DNA replication and other cellular processes, leading to bacterial death.
• Sulfadiazine: A sulfonamide antibiotic that inhibits bacterial growth by interfering with the synthesis of folic acid, an essential component for bacterial DNA synthesis.

Dosage and Administration:

• Application: The cream should be applied topically to the affected area. It is typically applied once or twice daily, depending on the severity of the infection and the healthcare provider’s instructions.
• Coverage: The cream should be applied in a layer approximately 1/16 inch (1.5mm) thick and should cover the entire affected area. If necessary, the area can be covered with a sterile dressing.

Precautions:

• Allergic Reactions: Patients with a known allergy to sulfonamides or silver should not use this medication.
• Renal or Hepatic Impairment: Use with caution in patients with renal or hepatic impairment, as the medication can be absorbed systemically.
• Newborns and Premature Infants: Use with caution in newborns and premature infants due to the risk of kernicterus (a type of brain damage that can result from high levels of bilirubin).