Tobramycin (Tobrazin) 3mg/ml (0.3% w/v) Opthalmic Solution Drops 10ml

Generic Name: TOBRAMYCIN

Brand Name: TOBRAZIN

Strength: 3mg / mL (0.3% w/v)

Form: Opthalmic Solution Drops

Manufacturer: SCOTT-EDIL PHARMACIA LTD. 

Imported and Distributed by: GREEN CORE PHARMA INC.

Classification: ANTIBACTERIAL

Indication/Uses: Tobramycin (Tobrazin) 3 mg/ml (0.3% w/v) Ophthalmic Solution is an antibiotic eye drop used to treat bacterial infections of the eye.

Patients should consult their healthcare provider for personalized advice and report any adverse reactions promptly. Regular follow-ups and appropriate monitoring are essential to ensure the safe and effective use of tobramycin ophthalmic solution.

Product Description:

Tobramycin (Tobrazin) 3mg/mL (0.3% w/v) Ophthalmic Solution Drops (10 mL) is an antibiotic eye drop solution that contains Tobramycin, an aminoglycoside antibiotic. It is used to treat eye infections caused by susceptible bacteria. Tobramycin works by inhibiting bacterial protein synthesis, thereby preventing the growth and multiplication of bacteria. This medication is specifically indicated for the treatment of bacterial infections of the eye such as conjunctivitis and keratitis, and is effective against a broad range of gram-negative and some gram-positive bacteria.

Indications:

Tobramycin Ophthalmic Solution is indicated for the treatment of:

• Bacterial Conjunctivitis: An infection of the conjunctiva (the lining of the eyelid and the surface of the eye) caused by susceptible bacteria.

• Bacterial Keratitis: Infection of the cornea with bacteria that can cause pain, swelling, and blurred vision.

• Other Bacterial Eye Infections: Any bacterial infections of the eye (excluding those caused by organisms resistant to tobramycin) where local treatment with an antibiotic is appropriate.

This medication may also be used in certain other bacterial eye infections as determined by a healthcare provider.

Dosages:

The usual dosing schedule for Tobramycin Ophthalmic Solution is as follows:

• For adults and children:

  • Initial Dose: One drop in the affected eye every 4 hours during waking hours (typically 5-6 times a day).

  • Maintenance: Once the infection starts to resolve, the dosing frequency may be reduced to 1 drop every 6-8 hours, as recommended by a healthcare provider.

• For severe infections:

  • In cases of severe infections, the dosage may be increased to one drop every hour or as instructed by a healthcare provider.

Instructions for use:

• Shake the bottle gently before use.

• Wash your hands before and after applying the drops.

• Tilt your head back, gently pull down the lower eyelid, and instill the prescribed number of drops into the pocket formed by the eyelid. Do not let the dropper tip touch the eye or any surface to avoid contamination.

• Close the eye for a minute and gently press the corner of the eye (near the nose) to prevent the liquid from draining away.

• Keep the cap tightly closed and store the bottle as per the manufacturer's recommendations.

The duration of treatment generally lasts from 5 to 7 days depending on the severity of the infection and the doctor’s instructions.

Side Effects:

Common side effects associated with Tobramycin Ophthalmic Solution include:

• Eye irritation: A mild stinging, burning, or itching sensation in the eyes may occur immediately after application.

• Conjunctival redness: Mild redness of the eye or the surrounding area.

• Blurry vision: Some patients may experience temporary blurred vision after using the drops.

• Eye discomfort: Sensitivity or discomfort in the eye, including dryness or a gritty feeling.

Serious but less common side effects that may require immediate medical attention include:

• Allergic reactions: Rash, itching, swelling of the face, lips, or throat, or difficulty breathing.

• Eye pain or worsening infection: If you experience significant eye pain or if your infection worsens despite using the drops, contact your healthcare provider.

• Vision problems: Any sudden loss of vision or significant visual disturbance should be reported immediately.

• Signs of systemic toxicity: Although rare, aminoglycosides like tobramycin can cause side effects such as hearing loss or kidney damage if absorbed into the bloodstream. Symptoms might include ringing in the ears (tinnitus) or changes in urinary patterns.

Contraindications:

Tobramycin Ophthalmic Solution should not be used in the following cases:

• Hypersensitivity: If the patient is allergic to Tobramycin or any other ingredients in the ophthalmic solution, it should not be used.

• Viral or Fungal Eye Infections: Tobramycin is effective against bacterial infections but not viral or fungal infections. Using this medication for viral conditions like herpes simplex or fungal infections can worsen the infection.

• Pre-existing Ear or Kidney Issues: Although the risk is low when used as directed for ophthalmic purposes, systemic absorption of tobramycin can lead to kidney or ear toxicity. It should be used with caution in patients with pre-existing kidney disease or a history of hearing problems.

• Pregnancy and Breastfeeding: While topical use limits systemic absorption, Tobramycin should be used during pregnancy or breastfeeding only if the potential benefit justifies the potential risk. It is always advisable to consult a healthcare provider before using any medication during pregnancy or while nursing.

Warnings and Precautions:

• Use with caution in patients with renal impairment: Tobramycin is excreted through the kidneys, so patients with kidney dysfunction should be monitored carefully.

• Avoid prolonged use: Long-term use of tobramycin ophthalmic solution may increase the risk of resistance to the antibiotic. It is recommended to complete the prescribed course as directed, but avoid unnecessary or extended use.

• Systemic Absorption: Although minimal, there is a risk of systemic absorption of tobramycin. If absorbed in large amounts, this can lead to potential side effects such as nephrotoxicity or ototoxicity (damage to the kidneys or ears). Always follow dosing instructions to minimize these risks.

• Avoid contact with other eye medications: If you are using other eye drops, wait at least 5-10 minutes between applying each different eye medication.

• Monitor for superinfection: Prolonged use of any antibiotic can lead to the growth of non-susceptible organisms, including fungi. If a secondary infection occurs, discontinue use and contact your healthcare provider.

Conclusion:

Tobramycin (Tobrazin) Ophthalmic Solution 3mg/mL (0.3% w/v) is an effective treatment for bacterial eye infections, providing quick relief from symptoms like redness, swelling, and discomfort. It is crucial to follow the prescribed dosage and not to use the drops beyond the recommended duration to avoid complications such as antibiotic resistance or side effects. Always consult your healthcare provider if you experience any unusual symptoms or if your condition does not improve.