Cefalexin (Exel) 100mg/ml Powder for Suspension Oral Drops 10ml

Certainly! Here’s an overview of Cefalexin (Exel) 100mg/ml Powder for Suspension Oral Drops 10ml:

Product Description:

Cefalexin (Exel) 100mg/ml Powder for Suspension Oral Drops is an oral antibiotic used to treat a wide range of bacterial infections. It contains Cefalexin, a first-generation cephalosporin antibiotic, which works by inhibiting the synthesis of the bacterial cell wall, leading to the destruction of the bacteria. Cefalexin is effective against both Gram-positive and Gram-negative bacteria.

This formulation is specifically designed for use in children or individuals who may have difficulty swallowing tablets or capsules. The powder is reconstituted with water to form an oral suspension, making it easy to measure and administer as drops. The bottle contains 10 ml of the suspension, with each milliliter providing 100 mg of Cefalexin.

Indications:

Cefalexin (Exel) is prescribed for the treatment of bacterial infections, including:

• Respiratory tract infections, such as bronchitis and pneumonia

• Urinary tract infections (e.g., cystitis, pyelonephritis)

• Skin and soft tissue infections, such as cellulitis or abscesses

• Ear infections (otitis media)

• Bone infections (osteomyelitis)

• Dental infections and prevention of infections after dental procedures

• Pharyngitis (sore throat)

• Sinus infections (sinusitis)

Note: Cefalexin is effective only against bacterial infections and is not used to treat viral infections (e.g., colds, flu).

Dosage:

The usual dosage of Cefalexin (Exel) for various conditions is as follows. However, the exact dosage and duration should be determined by a healthcare provider based on the patient's age, weight, and severity of the infection.

• For Adults and Children over 12 years:

  • The usual dose is 250 mg every 6 hours, or 500 mg every 12 hours.

  • The total daily dose can range from 1 to 4 grams depending on the infection being treated.

• For Children (1 year to 12 years):

  • The typical dose is 25-50 mg/kg body weight per day, divided into 2 or 3 doses.

  • For example, for a child weighing 20 kg, the dose could be between 500 mg to 1,000 mg per day, divided into 2-3 doses.

• For Infants (under 1 year):

  • The dosage is typically 25 mg/kg per day, divided into 2 or 3 doses.

Reconstitution:

• Add the recommended amount of water to the bottle containing the Cefalexin powder.

• Shake well until the powder is fully dissolved.

• The final concentration of the suspension is 100 mg/ml.

Note: Always follow the specific instructions provided on the product label or by your healthcare provider.

Side Effects:

Common side effects of Cefalexin (Exel) may include:

• Gastrointestinal issues:

  • Nausea, vomiting, diarrhea, or abdominal pain

  • These are the most common side effects and are usually mild.

• Allergic reactions (rare):

  • Rash, itching, swelling of the face or throat

  • Difficulty breathing (severe reactions, such as anaphylaxis, are rare but require immediate medical attention).

• Hematologic effects (rare):

  • Changes in blood counts, such as leukopenia (low white blood cells), eosinophilia (elevated eosinophils), or thrombocytopenia (low platelets)

• Liver and kidney issues (rare):

  • Elevated liver enzymes, jaundice (yellowing of the skin or eyes)

  • Renal dysfunction or changes in urine output, particularly in patients with pre-existing kidney conditions.

• Candidiasis (oral or vaginal yeast infections), which can occur with the use of antibiotics due to changes in normal microbial flora.

• Superinfections: Prolonged use of Cefalexin can lead to overgrowth of non-susceptible organisms, including fungi.

If any of these side effects become severe or persistent, contact a healthcare provider immediately.

Contraindications:

Cefalexin (Exel) should not be used in the following situations:

• Hypersensitivity (allergy) to Cefalexin, other cephalosporins, or any other component of the formulation.

  • A history of severe allergic reactions to penicillin or other beta-lactam antibiotics (such as amoxicillin) increases the risk of cross-reactivity with cephalosporins.

• Severe renal impairment: In individuals with severe kidney dysfunction, the dosage of Cefalexin may need to be adjusted, and close monitoring of renal function is required.

• History of gastrointestinal diseases: Particularly colitis (inflammation of the colon), as Cefalexin may alter the gut flora and lead to Clostridium difficile infection, a serious bacterial infection of the colon.

• Children under 6 months: Although Cefalexin is generally safe for use in infants, the liquid form (oral suspension) may be used with caution in infants under 6 months of age. Always consult a pediatrician for specific dosing recommendations.

Precautions:

• Pregnancy and Breastfeeding: Cefalexin is classified as Category B during pregnancy, indicating that it is generally considered safe for use, but it should only be used when necessary. It is excreted in breast milk in small amounts, so breastfeeding mothers should use it with caution and under a healthcare provider's guidance.

• Renal Impairment: Cefalexin is primarily excreted by the kidneys, so patients with renal dysfunction may require a dosage adjustment. Kidney function should be monitored during treatment.

• Drug Interactions: Cefalexin may interact with other medications:

  • Probenecid: This drug can reduce the renal clearance of Cefalexin, leading to higher blood concentrations and potential toxicity.

  • Anticoagulants (e.g., warfarin): There may be an increased risk of bleeding, so patients on anticoagulant therapy should be closely monitored.

  • Oral contraceptives: Although no significant interaction is typically seen, it is advised to use additional contraception methods when taking antibiotics, including Cefalexin.

Storage:

• Store Cefalexin (Exel) 100mg/ml Powder for Suspension Oral Drops at room temperature (20°C to 25°C / 68°F to 77°F).

• Keep the bottle tightly closed, away from heat, moisture, and direct light.

• Once reconstituted, the suspension should be stored in the refrigerator and used within 14 days.

• Keep out of reach of children.

This summary provides general information about Cefalexin (Exel) 100mg/ml Powder for Suspension Oral Drops. Always consult your healthcare provider or pharmacist for specific medical advice, dosage instructions, and information about potential interactions with other medications.