Cefixime Trihydrate (Flamifix 200) 200mg Antibacterial Capsule 10's

Certainly! Below is the detailed information for Cefixime Trihydrate (Flamifix 200) 200mg Antibacterial Capsule 10's:

Product Description:

Cefixime Trihydrate (Flamifix 200) is an antibacterial medication belonging to the class of cephalosporin antibiotics. It is used to treat a wide range of bacterial infections by inhibiting the growth of bacteria. Cefixime works by interfering with the bacterial cell wall synthesis, leading to the destruction of the bacteria.

Flamifix 200 comes in the form of 200mg capsules and is typically packaged in a bottle containing 10 capsules. It is generally prescribed for infections caused by susceptible bacteria, providing effective relief from conditions such as respiratory infections, urinary tract infections, and skin infections.

Indications:

Flamifix 200 (Cefixime Trihydrate 200mg) is indicated for the treatment of the following bacterial infections:

1. Upper Respiratory Tract Infections (URTI):

   • Pharyngitis (sore throat)

   • Tonsillitis

   • Sinusitis (inflammation of the sinuses)

2. Lower Respiratory Tract Infections (LRTI):

   • Bronchitis

   • Pneumonia

3. Urinary Tract Infections (UTI):

   • Cystitis (bladder infection)

   • Pyelonephritis (kidney infection)

4. Sexually Transmitted Infections (STIs):

   • Gonorrhea (caused by Neisseria gonorrhoeae)

5. Skin and Soft Tissue Infections:

   • Impetigo

   • Cellulitis

6. Otitis Media: Middle ear infections, especially in children.

Flamifix 200 is effective against gram-positive and gram-negative bacteria, including Haemophilus influenzae, Streptococcus pneumoniae, and Escherichia coli.

Dosage:

The typical dosage for Cefixime Trihydrate (Flamifix 200mg) is as follows:

• Adults:

  • 200mg once daily or 100mg twice daily, depending on the severity of the infection.

  • For gonorrhea (uncomplicated), a single dose of 400mg may be administered.

• Pediatric Patients (over 6 months old):

  • The usual pediatric dose is 8mg/kg/day in two divided doses, or once daily. The dose should be tailored to the weight of the child and the type of infection being treated.

• Renal Impairment:

  • In patients with impaired kidney function, the dose of Cefixime may need to be adjusted. Dosage adjustments are typically based on the degree of renal dysfunction.

It is recommended to take the capsules with a full glass of water, with or without food. Ensure to complete the full prescribed course of antibiotics, even if symptoms improve before finishing the medication.

Side Effects:

As with all medications, Cefixime Trihydrate (Flamifix 200mg) may cause side effects, although not everyone experiences them. Common and less common side effects include:

Common Side Effects:

• Diarrhea or loose stools

• Nausea or vomiting

• Abdominal pain or discomfort

• Headache

• Dizziness

• Rash

• Fatigue

Serious Side Effects:

• Severe allergic reactions: Symptoms may include swelling of the face, lips, or throat, difficulty breathing, hives, and anaphylaxis (a severe allergic reaction requiring immediate medical attention).

• Clostridium difficile-associated diarrhea (C. difficile): Cefixime may increase the risk of developing severe diarrhea, which can be caused by an overgrowth of Clostridium difficile bacteria in the colon.

• Hepatic (liver) issues: Rarely, liver problems such as hepatitis or jaundice (yellowing of the skin and eyes) may occur.

• Blood-related issues: Rarely, low blood cell counts, such as neutropenia (low white blood cell count), thrombocytopenia (low platelet count), or anemia (low red blood cell count), may occur.

• Renal (kidney) problems: Cefixime can cause kidney-related issues in rare cases, such as acute kidney failure or interstitial nephritis.

• Severe skin reactions: Rare but serious reactions like toxic epidermal necrolysis (TEN) or Stevens-Johnson syndrome (SJS), which are severe skin rashes requiring urgent medical attention.

If any of these serious side effects occur, seek immediate medical help.

Contraindications:

Cefixime Trihydrate (Flamifix 200mg) should not be used in the following situations:

• Hypersensitivity (Allergy) to Cefixime or Cephalosporin Antibiotics: Cefixime is contraindicated in patients who are allergic to cephalosporin antibiotics (e.g., cephalexin, cefotaxime) or any of the ingredients in the medication.

• Severe Renal Impairment: If a patient has severe kidney disease or is undergoing dialysis, caution is needed, and dose adjustments may be required.

• History of Anaphylaxis to Penicillins: Patients with a known severe allergic reaction (anaphylaxis) to penicillins or other beta-lactam antibiotics may have a higher risk of cross-reactivity with cephalosporins, including Cefixime.

Precautions:

• Pregnancy: Cefixime is classified as Category B (based on animal studies), meaning it is generally considered safe during pregnancy but should only be used when clearly needed. Consult your healthcare provider before using during pregnancy.

• Breastfeeding: Cefixime passes into breast milk in small amounts. It is generally considered safe to use while breastfeeding, but it is advisable to consult with a healthcare provider before taking the medication.

• Gastrointestinal Issues: Cefixime can alter the normal bacteria in the gut, potentially leading to diarrhea. If severe diarrhea occurs, especially if it is watery or bloody, seek immediate medical attention as it may indicate a Clostridium difficile infection.

• Kidney Function: In patients with impaired kidney function, dosage adjustments may be required, and renal function should be monitored.

Drug Interactions:

Cefixime can interact with several medications, including:

• Antacids: Antacids containing aluminum or magnesium may decrease the absorption of Cefixime, potentially reducing its effectiveness. It is best to separate the doses of Cefixime and antacids by at least 2 hours.

• Probenecid: The concomitant use of probenecid (used to treat gout) may increase the levels of Cefixime in the blood by inhibiting its renal excretion.

• Blood Thinners (e.g., Warfarin): Cefixime may enhance the effect of blood thinners, increasing the risk of bleeding. Regular monitoring of prothrombin time (INR) is recommended when taking both medications together.

• Other Antibiotics: Combining Cefixime with other antibiotics may alter its effectiveness. It is essential to follow your healthcare provider's guidance on the use of multiple antibiotics.

Summary:

Cefixime Trihydrate (Flamifix 200) is an antibacterial medication that is primarily used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, gonorrhea, and skin infections. The typical dose is 200mg once daily for most infections, although the dose may be adjusted for more severe infections or in special populations.

Common side effects include diarrhea, nausea, and headache, while more serious side effects like severe allergic reactions, liver problems, and kidney issues are rare but possible. It is contraindicated in patients with a known allergy to cephalosporin antibiotics and should be used with caution in those with severe renal impairment.

As always, it is important to follow the prescribed dosage regimen, complete the full course of antibiotics, and consult a healthcare provider if there are any concerns or adverse reactions during treatment.