Cefuroxime (Keef 250) 250mg/5ml Powder for Oral Suspension 50ml

 250mg/5ml Powder for Oral Suspension

ANTIBACTERIAL (CEPHALOSPORINS)

Here’s a detailed breakdown of Cefuroxime (Keef 250) 250mg/5ml Powder for Oral Suspension 50ml:

Product Description:

Cefuroxime (Keef 250) is an antibiotic belonging to the cephalosporin class. It is available as a 250mg/5ml powder for oral suspension, typically provided in a 50ml bottle. The active ingredient, Cefuroxime, works by inhibiting bacterial cell wall synthesis, thereby killing or inhibiting the growth of susceptible bacteria.

Cefuroxime is a broad-spectrum antibiotic effective against both gram-positive and gram-negative bacteria, making it useful for a wide range of infections.

Once prepared by adding water to the powder, the oral suspension is ready to be taken.

Indications:

Cefuroxime (Keef 250) is used for the treatment of various infections caused by susceptible bacteria, including:

1. Upper Respiratory Tract Infections (URIs):

   • Sinusitis

   • Pharyngitis (sore throat)

   • Tonsillitis

2. Lower Respiratory Tract Infections (LRIs):

   • Bronchitis

   • Pneumonia

3. Ear Infections:

   • Otitis media (middle ear infections)

4. Urinary Tract Infections (UTIs):

   • Cystitis

   • Pyelonephritis (kidney infections)

5. Skin and Soft Tissue Infections:

   • Cellulitis

   • Abscesses

   • Wounds

6. Gonorrhea:

   • Treatment of gonococcal infections caused by susceptible organisms.

7. Bone and Joint Infections:

   • Osteomyelitis (bone infection)

8. Gastrointestinal Infections:

   • Peritonitis and other intra-abdominal infections.

Dosage and Administration:

The dosage of Cefuroxime (Keef 250) depends on the type and severity of the infection and the age of the patient. This medication should be taken according to the doctor’s instructions. Below are general guidelines:

Adult Dosage:

• Common adult dosage: 250mg to 500mg every 12 hours, depending on the infection.

• In more severe infections, or for more resistant organisms, the dose may be increased to 1g per day.

Pediatric Dosage (based on body weight):

• Children typically receive 20mg to 30mg per kg of body weight per day, divided into two doses.

• For infants and young children, the dosage may range from 125mg to 250mg every 12 hours.

Administration:

• Cefuroxime (Keef 250) should be taken with food to improve absorption and minimize gastrointestinal side effects.

• The powder should be reconstituted with water as per the instructions on the label before taking.

• The suspension should be shaken well before each dose to ensure uniformity.

Renal Impairment:

• Dose adjustments may be necessary for individuals with severe renal impairment.

Side Effects:

While Cefuroxime (Keef 250) is generally well-tolerated, some patients may experience side effects, including:

Common Side Effects:

• Gastrointestinal issues:

  • Nausea, vomiting, diarrhea, or abdominal pain.

• Rash or itching.

Less Common Side Effects:

• Fungal infections, such as oral thrush or vaginal yeast infections.

• Headache or dizziness.

• Altered liver enzymes: This may be seen in liver function tests.

Serious Side Effects (Rare, but may require immediate medical attention):

• Severe allergic reactions (anaphylaxis), which can include difficulty breathing, swelling of the face, lips, or throat, and rash.

• Severe diarrhea (often associated with Clostridium difficile infection), characterized by bloody stools, fever, or abdominal pain.

• Hematologic effects, such as low white blood cell count (leukopenia) or low platelet count (thrombocytopenia).

• Liver problems, such as jaundice (yellowing of the skin or eyes).

If any of these serious side effects occur, immediate medical attention should be sought.

Contraindications:

Cefuroxime (Keef 250) should not be used in the following situations:

1. Hypersensitivity (Allergy) to Cephalosporins or Penicillins:

   • Patients who have a known allergy to cefuroxime, other cephalosporins, or penicillin antibiotics should not take this drug due to the potential for serious allergic reactions.

2. Severe Renal Impairment:

   • Severe renal impairment may require dosage adjustment or avoiding use altogether due to the increased risk of accumulation and toxicity.

3. History of Colitis or Gastrointestinal Disorders:

   • Cefuroxime should be used cautiously in patients with a history of gastrointestinal disorders, especially colitis (inflammation of the colon), as the antibiotic can disrupt normal gut flora and precipitate Clostridium difficile-associated diarrhea.

Precautions:

1. Allergic Reactions:

   • Cefuroxime (Keef 250) should be used with caution in patients with a history of allergies, especially to other antibiotics like penicillins or cephalosporins. Severe allergic reactions such as anaphylaxis can occur.

2. Superinfection:

   • Prolonged use of Cefuroxime may lead to superinfections, where resistant organisms or fungal infections (e.g., candida infection) can proliferate. If symptoms of a new infection develop, treatment should be reevaluated.

3. Clostridium Difficile-Associated Diarrhea (CDAD):

   • Like other antibiotics, Cefuroxime can cause Clostridium difficile-associated diarrhea, a potentially severe complication. If patients develop significant diarrhea during or after treatment, further evaluation is necessary.

4. Renal Function:

   • Cefuroxime should be used cautiously in patients with renal insufficiency. Dose adjustments may be required in these cases to prevent accumulation and toxicity.

5. Pregnancy and Lactation:

   • Cefuroxime is categorized as a pregnancy category B drug, which means it is generally considered safe during pregnancy when used as prescribed. However, it should only be used if clearly needed and prescribed by a healthcare provider.

   • Cefuroxime is also excreted into breast milk, but in low amounts. It is generally considered safe for use while breastfeeding, but it is important to consult with a healthcare provider before use.

Summary:

Cefuroxime (Keef 250) 250mg/5ml powder for oral suspension is a broad-spectrum antibiotic effective against a wide range of bacterial infections, including those affecting the respiratory, urinary, gastrointestinal, and skin systems. It is commonly used in both adults and children to treat infections caused by susceptible bacteria.

• Indications: Treats a variety of infections, including URIs, LRIs, skin infections, and UTIs.

• Dosage: Typically 250mg every 12 hours for adults, with pediatric doses based on weight.

• Side Effects: Gastrointestinal upset, rash, allergic reactions, and superinfection are common, with more serious reactions including anaphylaxis and Clostridium difficile diarrhea.

• Contraindications: Should not be used in those with penicillin or cephalosporin allergies, severe renal impairment, or a history of colitis.

This medication should always be taken as prescribed and under the supervision of a healthcare provider to ensure optimal results and minimize potential risks.