Cetirizine Hydrochloride (Zyrine) 5mg/5ml Oral Solution Syrup 60ml

Generic Name: Cetirizine Hydrochloride

Brand Name: Zyrine

Strength: 5mg / 5mL

Form: Syrup

Manufacturer: Scheele Laboratories Phils., Inc.

Imported and Distributed by: 

Classification: ANTIHISTAMINE

Indication/Uses: Patients are advised to follow their healthcare provider's instructions regarding the dosage and to report any adverse reactions. Regular monitoring and consultations with a healthcare provider are recommended to ensure the safe and effective use of cetirizine.

Product Description:

Cetirizine Hydrochloride (Zyrine) 5mg/5mL Oral Solution Syrup 60mL is an antihistamine in the form of an oral liquid suspension. Each 5 mL of the syrup contains 5 mg of cetirizine hydrochloride, which is commonly used to treat allergic conditions. Cetirizine is a second-generation antihistamine that works by blocking the action of histamine, a substance produced by the body during allergic reactions. It helps reduce symptoms such as sneezing, runny nose, itchy eyes, and throat irritation caused by seasonal allergies (hay fever) or other allergic reactions. This formulation is particularly useful for individuals who have difficulty swallowing tablets, such as children or the elderly.

Indications:

Cetirizine Hydrochloride (Zyrine) Oral Solution Syrup is indicated for:

• Seasonal Allergic Rhinitis: To relieve symptoms such as sneezing, runny or itchy nose, and itchy or watery eyes caused by hay fever or other seasonal allergies.

• Perennial Allergic Rhinitis: To treat allergic reactions that occur year-round, such as those caused by dust mites, pet dander, or mold.

• Urticaria (Hives): To treat itching and swelling caused by chronic urticaria (hives), which can be due to an allergic reaction.

• Allergic Conjunctivitis: To reduce eye irritation and itching caused by allergies.

Dosages:

The dosage of Cetirizine Hydrochloride (Zyrine) Oral Solution Syrup varies based on the patient’s age and condition. It is important to follow the recommended dose to minimize side effects.

• Adults and Children Over 12 Years:

  • 10 mL (10 mg) once daily, or 5 mL (5 mg) twice daily, depending on the severity of symptoms. Do not exceed 10 mg per day.

• Children 6 to 12 Years:

  • 5 mL (5 mg) once daily, or 2.5 mL (2.5 mg) twice daily.

• Children 2 to 5 Years:

  • 2.5 mL (2.5 mg) once daily, or 1.25 mL (1.25 mg) twice daily.

• Children Under 2 Years:

  • The use of cetirizine in children younger than 2 years should only be done under the advice and supervision of a healthcare provider.

Note: Always use the provided measuring spoon or dropper to ensure accurate dosing. The syrup should be taken orally, and it can be consumed with or without food. It is recommended to avoid alcohol consumption during treatment, as it can increase the sedative effects of cetirizine.

Side Effects:

Common side effects of Cetirizine Hydrochloride (Zyrine) Oral Solution Syrup include:

• Drowsiness or Fatigue: Cetirizine may cause mild drowsiness or tiredness, especially in some individuals.

• Dry Mouth: Some people may experience dryness in the mouth while using cetirizine.

• Headache: A mild headache may occur in some individuals.

• Gastrointestinal Issues: Symptoms such as stomach pain, nausea, or diarrhea are possible but uncommon.

• Dizziness: Some users may experience dizziness or lightheadedness.

Less common but more serious side effects may include:

• Allergic Reactions: Rarely, cetirizine can cause a serious allergic reaction, with symptoms such as swelling of the face, lips, tongue, or throat, or difficulty breathing. If this occurs, seek immediate medical attention.

• Severe Drowsiness: In rare cases, cetirizine can cause excessive drowsiness or sedation, particularly when combined with alcohol or other sedating medications.

• Tachycardia: Rapid heart rate is a rare but possible side effect of cetirizine.

• Urinary Retention: In some individuals, cetirizine may cause difficulty in urination or urinary retention, especially in older adults.

If any of the following serious side effects occur, seek medical attention immediately:

• Severe allergic reactions: Difficulty breathing, swelling of the lips, face, or throat.

• Severe drowsiness or confusion.

• Irregular heartbeat or signs of heart-related issues.

• Signs of overdose: Symptoms such as extreme drowsiness, agitation, or rapid heartbeat may indicate an overdose.

Contraindications:

Cetirizine Hydrochloride (Zyrine) Oral Solution Syrup should be avoided or used with caution in the following situations:

• Hypersensitivity: If the patient is allergic to cetirizine, hydroxyzine, or any of the other ingredients in the syrup, it should be avoided.

• Severe Liver or Kidney Dysfunction: Cetirizine is metabolized by the liver and excreted through the kidneys. In individuals with severe liver or kidney impairment, the dosage may need to be adjusted, or cetirizine may be contraindicated.

• Children Under 2 Years: The use of cetirizine in children under 2 years should be avoided unless recommended by a healthcare provider, as safety and effectiveness have not been established in this age group.

• Pregnancy: Cetirizine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is considered a Category B drug, meaning animal studies have not shown harm, but there are insufficient studies in humans.

• Breastfeeding: Cetirizine can pass into breast milk, so it should only be used during breastfeeding if necessary and under the supervision of a healthcare provider.

Warnings and Precautions:

• Drowsiness: Cetirizine can cause drowsiness in some individuals, which may impair the ability to drive or operate machinery. It is advised to assess individual tolerance before engaging in such activities.

• Alcohol and Sedatives: Alcohol and other central nervous system depressants can enhance the sedative effects of cetirizine. It is recommended to avoid alcohol while taking this medication.

• Kidney or Liver Disease: Patients with kidney or liver disease should use cetirizine with caution. Dosage adjustments may be necessary, and a healthcare provider should monitor the patient for side effects.

• Overdose Risk: Symptoms of overdose may include excessive drowsiness, agitation, rapid heart rate, or restlessness. If overdose is suspected, seek medical attention immediately.

• Pregnancy and Breastfeeding: Consult with a healthcare provider before using cetirizine if you are pregnant or breastfeeding. While cetirizine is generally considered safe during pregnancy (Category B), it should only be used if necessary.

Conclusion:

Cetirizine Hydrochloride (Zyrine) 5mg/5mL Oral Solution Syrup 60mL is a helpful treatment for managing the symptoms of allergies, including hay fever, allergic rhinitis, and chronic urticaria (hives). It is easy to use and suitable for those who prefer or need a liquid form of medication, such as children or individuals who have difficulty swallowing tablets. Cetirizine is generally well tolerated but should be used with caution in individuals with liver or kidney impairments and those who are pregnant or breastfeeding. As with any medication, it is important to follow the prescribed dosage and be mindful of any potential side effects. Always consult a healthcare provider before starting or adjusting the dosage of cetirizine, especially for children under 2 years or individuals with pre-existing health conditions.