Ciprofloxacin (Acipro) 2mg/ml 200mg/100ml Solution for I.V Infusion 100ml

Product Description:

Ciprofloxacin (Acipro) 2mg/ml (200mg/100ml) Solution for IV Infusion is a broad-spectrum antibiotic used to treat a wide range of bacterial infections. It contains Ciprofloxacin, a fluoroquinolone antibiotic, which works by inhibiting bacterial enzymes DNA gyrase and topoisomerase IV, preventing bacterial DNA replication and thus halting the growth of bacteria.

This IV formulation is specifically designed for hospital or clinical use and is administered when oral therapy is not possible or when rapid therapeutic effects are required. It is particularly useful in treating serious infections where quick intervention is essential. The product comes in a 100ml vial with a 200mg dose of Ciprofloxacin, and the solution should be administered via slow intravenous infusion.

Key Features:

• Active Ingredient: Ciprofloxacin 200mg/100ml.

• Formulation: Ready-to-use intravenous (IV) solution.

• Broad-Spectrum Activity: Effective against many gram-negative and gram-positive bacteria.

• Indications: Treatment for severe bacterial infections like urinary tract infections, respiratory infections, and skin infections.

• Convenient Infusion: For patients who cannot take oral medications or require rapid action.

Indications:

Ciprofloxacin (Acipro) IV infusion is indicated for the treatment of the following infections:

1. Urinary Tract Infections (UTIs):

   • Acute and chronic urinary infections such as pyelonephritis and cystitis.

2. Lower Respiratory Tract Infections:

   • Including pneumonia, bronchitis, and other lung infections.

3. Abdominal Infections:

   • Such as peritonitis or infections following abdominal surgery.

4. Skin and Soft Tissue Infections:

   • For conditions like cellulitis, abscesses, and infected wounds.

5. Bone and Joint Infections:

   • Osteomyelitis and other bone infections.

6. Sepsis (Blood Infection):

   • For the management of severe systemic bacterial infections.

7. Bacterial Endocarditis:

   • Infections of the heart valves caused by bacteria.

8. Prophylaxis:

   • Used for prevention of infections in immunocompromised patients or after certain surgeries.

Dosage:

The dosage of Ciprofloxacin (Acipro) IV infusion varies depending on the infection being treated, patient condition, and renal function. Below are general dosing guidelines:

• Standard Dose:

  • 200mg every 12 hours via IV infusion for most serious infections.

  • The infusion should be administered over a 60-minute period.

• Severe Infections:

  • 400mg every 12 hours (infused over 60 minutes).

• Urinary Tract Infections:

  • 200mg every 12 hours for uncomplicated infections.

  • 400mg every 12 hours for complicated UTIs or pyelonephritis.

• Renal Impairment:

  • In patients with renal impairment, the dose should be adjusted according to the patient's renal function (creatinine clearance). Lower doses are required in patients with creatinine clearance <30 mL/min.

Administration:

• Infusion: Administer as a slow IV infusion over 60 minutes.

• The solution should be diluted as necessary and should not be mixed with other medications unless specifically recommended.

• Injection site: Use a large vein to avoid irritation.

Side Effects:

Common side effects of Ciprofloxacin (Acipro) IV infusion include:

• Gastrointestinal: Nausea, vomiting, diarrhea, abdominal discomfort.

• Headache: Mild to moderate headache, especially with higher doses.

• Dizziness or light-headedness.

• Skin reactions: Rash or itching may develop.

• Elevated liver enzymes: Occasional liver enzyme changes or mild liver dysfunction.

• Injection site reactions: Pain, redness, or swelling at the infusion site.

Serious side effects include:

• Tendinitis or tendon rupture: Ciprofloxacin can increase the risk of tendonitis or tendon rupture, especially in elderly patients or those on corticosteroids.

• Severe allergic reactions (Anaphylaxis): Symptoms may include difficulty breathing, swelling of the face, lips, or throat, and rash.

• Central nervous system effects: Seizures, confusion, or hallucinations, especially in older adults or those with renal dysfunction.

• QT prolongation: Ciprofloxacin can cause heart rhythm abnormalities, including QT interval prolongation, which may lead to serious arrhythmias.

• Clostridium difficile-associated diarrhea: A serious gastrointestinal condition, potentially life-threatening.

• Peripheral neuropathy: Symptoms like tingling or numbness in the extremities.

Contraindications:

Ciprofloxacin (Acipro) IV infusion is contraindicated in the following situations:

1. Hypersensitivity to Ciprofloxacin: If allergic to Ciprofloxacin or other fluoroquinolones, it should not be used.

2. Tendon disorders: Ciprofloxacin is associated with an increased risk of tendonitis and tendon rupture, particularly in older adults or those on corticosteroid therapy.

3. Severe renal impairment: Patients with severe renal dysfunction (creatinine clearance <30 mL/min) should use Ciprofloxacin with caution, and the dose should be adjusted.

4. Pregnancy: Ciprofloxacin is not recommended during pregnancy, especially in the first trimester, due to potential risks to the fetus.

5. Breastfeeding: Ciprofloxacin can be excreted into breast milk and should be avoided during breastfeeding unless absolutely necessary.

6. Myasthenia Gravis: Ciprofloxacin can exacerbate the symptoms of myasthenia gravis (muscle weakness).

Warnings and Precautions:

• QT prolongation: Ciprofloxacin may cause QT interval prolongation, especially in patients with heart conditions or those on other medications that affect the heart's rhythm.

• Gastrointestinal: Be cautious for signs of Clostridium difficile-associated diarrhea, which can be severe and life-threatening.

• Neurological effects: Ciprofloxacin may cause CNS effects, including seizures or hallucinations, particularly in elderly patients or those with impaired renal function.

• Renal and Hepatic Function: Monitor renal and hepatic function during prolonged use.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, have been reported. If these occur, discontinue treatment and seek immediate medical assistance.

Drug Interactions:

• Antacids: These can decrease the absorption of Ciprofloxacin. It should be taken at least 2 hours before or 6 hours after antacids or other medications containing aluminum, magnesium, or iron.

• Theophylline: Ciprofloxacin may increase theophylline levels, increasing the risk of theophylline toxicity (e.g., seizures).

• Warfarin: Ciprofloxacin can enhance the effect of warfarin, leading to an increased risk of bleeding. Regular monitoring of the INR is recommended.

• NSAIDs: Combining Ciprofloxacin with NSAIDs may increase the risk of CNS side effects, such as seizures.

• Corticosteroids: Concurrent use with corticosteroids increases the risk of tendon rupture.

Storage:

• Store Ciprofloxacin (Acipro) 2mg/ml (200mg/100ml) Solution for IV Infusion at room temperature (15°C to 25°C).

• Protect the solution from light and keep it in its original container.

• Do not freeze the solution.

• Once opened, the solution should be used immediately or according to the manufacturer's instructions.

Conclusion:

Ciprofloxacin (Acipro) 2mg/ml (200mg/100ml) Solution for IV Infusion is a highly effective antibiotic used to treat a broad range of serious bacterial infections. It is particularly useful in hospital settings for infections that require rapid intervention or for patients who cannot take oral antibiotics. Like all medications, it comes with potential side effects, including gastrointestinal disturbances, allergic reactions, and risks of tendon damage, so it should be used under proper medical supervision. Always follow the prescribed dosage and administration guidelines to ensure the most effective treatment.