Clopidogrel (Copide) 75mg Film Coated Tablets 100's

Antithrombotic Agent
(Platelet Aggregation Inhibitor)

Certainly! Below is a detailed breakdown of Clopidogrel (Copide) 75mg Film-Coated Tablets 100's:

Product Description:

Clopidogrel (Copide) 75mg Film-Coated Tablets contain Clopidogrel as the active ingredient. Clopidogrel is an antiplatelet medication that works by inhibiting platelet aggregation, reducing the risk of blood clot formation. It does so by selectively and irreversibly inhibiting the P2Y12 receptor on platelets, which prevents ADP (adenosine diphosphate) from activating the platelets and making them sticky. This reduces the ability of platelets to clump together and form harmful clots, which is important in the prevention of various cardiovascular and cerebrovascular events.

Each tablet contains 75 mg of Clopidogrel, and the pack contains 100 film-coated tablets for oral administration.

Indications:

Clopidogrel (Copide 75mg) is used for the prevention of a variety of cardiovascular and cerebrovascular conditions, including:

1. Prevention of atherothrombotic events (events related to blood clots forming in arteries):

   • Acute coronary syndrome (ACS): For patients with unstable angina or non-ST elevation myocardial infarction (NSTEMI) or ST elevation myocardial infarction (STEMI), to reduce the risk of further heart attacks, strokes, and death.

   • After a heart attack (myocardial infarction): To reduce the risk of a second heart attack.

   • After a stroke (ischemic cerebrovascular events): To reduce the risk of future strokes in patients who have had an ischemic stroke (caused by a clot).

   • Peripheral arterial disease (PAD): To reduce the risk of cardiovascular events in patients with PAD.

2. Prevention of thrombosis after percutaneous coronary intervention (PCI):

   • Clopidogrel is used in patients undergoing procedures like coronary stenting to prevent blood clots from forming around the stent.

3. Post-surgical prevention: To prevent clot formation in patients who have undergone surgery such as coronary artery bypass grafting (CABG) or stent placement.

Dosages:

The typical dose of Clopidogrel (Copide 75mg) is as follows:

1. For Acute Coronary Syndrome (ACS):

   • Loading dose: A 300 mg loading dose is usually given initially (either as a single dose or divided over a few hours).

   • Maintenance dose: The usual dose after the loading dose is 75 mg once daily.

2. For Prevention of Stroke, Myocardial Infarction, or Peripheral Arterial Disease (PAD):

   • Standard maintenance dose: 75 mg once daily, with or without food.

3. After Percutaneous Coronary Intervention (PCI) or Coronary Stent Placement:

   • Loading dose: Typically, 300 mg or 600 mg may be given initially depending on the clinical situation.

   • Maintenance dose: 75 mg once daily.

The dosage may be adjusted based on the individual patient's risk, medical condition, and treatment plan, as determined by a healthcare provider.

Side Effects:

While Clopidogrel is generally well-tolerated, it can cause side effects in some individuals. Common and serious side effects include:

Common Side Effects:

• Bleeding: As Clopidogrel works to prevent blood clotting, bleeding is a known risk, especially:

  • Nosebleeds

  • Gum bleeding

  • Easy bruising

• Diarrhea

• Abdominal pain

• Indigestion or heartburn

• Headache

• Dizziness

Serious Side Effects:

• Severe bleeding: Internal bleeding, including gastrointestinal bleeding, or bleeding in the brain (intracranial hemorrhage) can occur. Signs of severe bleeding may include:

  • Unusual bruising or pinpoint red spots on the skin

  • Coughing up blood or vomit that looks like coffee grounds

  • Black, tarry stools

  • Severe headache or sudden weakness

• Thrombotic thrombocytopenic purpura (TTP): A rare but serious condition that involves blood clot formation in small blood vessels, leading to low platelet counts and organ damage. Symptoms of TTP include:

  • Fever

  • Fatigue

  • Bruising

  • Jaundice (yellowing of the skin or eyes)

• Severe allergic reactions, including:

  • Rash or itching

  • Swelling of the face, lips, or throat

  • Difficulty breathing

If any of these serious side effects occur, stop taking the medication and seek emergency medical help.

Contraindications:

Clopidogrel (Copide 75mg) should not be used in the following situations:

1. Hypersensitivity (Allergy):

   • If the patient is allergic to Clopidogrel or any other components of the tablet.

2. Active Bleeding Disorders:

   • Patients with active bleeding disorders, such as peptic ulcer disease, intracranial hemorrhage, or gastrointestinal bleeding, should not use Clopidogrel.

3. Severe Liver Impairment:

   • Patients with severe liver dysfunction or cirrhosis should avoid Clopidogrel, as it may increase the risk of bleeding and other complications.

4. History of Hemorrhagic Stroke:

   • Clopidogrel should not be used in patients who have had a hemorrhagic stroke (a stroke caused by bleeding in the brain), as it can increase the risk of further bleeding.

5. Concurrent Use with Certain Medications:

   • Clopidogrel should be used with caution when combined with other medications that increase the risk of bleeding, such as anticoagulants (e.g., warfarin), NSAIDs (e.g., ibuprofen), and other antiplatelet drugs (e.g., aspirin, ticagrelor). Concurrent use may require dose adjustments and close monitoring.

6. Pregnancy and Breastfeeding:

   • Clopidogrel is not recommended during pregnancy unless absolutely necessary, as the safety of its use in pregnant women has not been well established.

   • Breastfeeding: It is not known whether Clopidogrel passes into breast milk, so it should be used with caution in breastfeeding mothers. A healthcare provider should be consulted to assess potential risks and benefits.

Precautions:

• Risk of Bleeding: Since Clopidogrel inhibits platelet aggregation, there is an increased risk of bleeding. Regular monitoring of platelet count and other laboratory tests may be required, especially in patients with a history of bleeding disorders.

• Surgical Procedures: Clopidogrel should be discontinued at least 5 days prior to elective surgeries to reduce the risk of bleeding during and after the procedure. Always inform your surgeon or healthcare provider that you are taking Clopidogrel.

• Renal Impairment: In patients with moderate renal impairment, Clopidogrel should be used with caution, and the healthcare provider may adjust the dose or monitor kidney function closely.

• Discontinuation of Therapy: If you need to stop Clopidogrel for any reason, this should be done under medical supervision. Suddenly discontinuing the medication may increase the risk of cardiovascular events.

Important Notes:

• Compliance: It's important to take Clopidogrel as prescribed, and not to skip doses, as missing doses can reduce the effectiveness of the treatment.

• Missed Dose: If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not take two doses at once to make up for a missed dose.

• Monitoring: Regular blood tests may be required to monitor your platelet count and liver function during treatment.

Conclusion:

Clopidogrel (Copide 75mg) is an effective antiplatelet medication used to prevent cardiovascular and cerebrovascular events, particularly in patients at high risk for heart attack, stroke, or blood clots. It is commonly prescribed after heart-related surgeries or for patients with a history of cardiovascular disease. Although it is generally well tolerated, it carries a risk of bleeding, which requires careful monitoring, especially when used in combination with other medications or in individuals with certain medical conditions. Regular follow-ups with a healthcare provider are essential for ensuring safe and effective use of Clopidogrel.