Hyoscine N Butylbromide (Hyozani) 20mg/ml Solution For Injection (I.M/I.V/S.C) Antispasmodic 1ml x Ampoules 10's

Product Description:

Hyoscine N Butylbromide (Hyozani) 20mg/ml Solution for Injection is an antispasmodic medication used to relieve muscle spasms, particularly in the gastrointestinal tract, genitourinary system, and other smooth muscles. The active ingredient, Hyoscine N-Butylbromide, is a muscarinic receptor antagonist that works by inhibiting the action of acetylcholine at muscarinic receptors on smooth muscle, thereby preventing muscle contractions and spasms. This medication is typically used for the short-term relief of spasm-related conditions.

Each 1ml ampoule contains 20 mg of Hyoscine N Butylbromide, and each pack contains 10 ampoules. It is administered via intramuscular (IM), intravenous (IV), or subcutaneous (SC) injection, making it suitable for rapid action in acute situations.

Indications:

Hyoscine N Butylbromide (Hyozani) 20mg/ml Solution for Injection is indicated for:

• Spasm Relief: To relieve smooth muscle spasms in the gastrointestinal tract (such as those due to irritable bowel syndrome or gastrointestinal colic), urinary tract, and biliary tract.

• Preoperative Medication: To reduce excessive salivation and prevent vagal reactions during anesthesia.

• Acute Abdominal Pain: It may be used to treat acute abdominal pain due to spasms or colic in the gastrointestinal system.

• Postoperative Care: Used to relieve spasms of the bladder or other smooth muscles post-surgery.

Dosage:

Hyoscine N Butylbromide (Hyozani) 20mg/ml Solution for Injection is typically administered by a healthcare professional. The dosage may vary depending on the condition being treated, the patient's response, and their medical history.

• Adults:

  • Initial Dose: The usual dose is 20 mg (1 ml), which can be administered intramuscularly (IM), intravenously (IV), or subcutaneously (SC).

  • The dose may be repeated every 4 to 6 hours if necessary, but do not exceed 100 mg (5 ml) per day.

• Pediatric Patients:

  • Children: The safety and efficacy of Hyoscine N Butylbromide in children have not been well established, so it is not typically recommended for use in pediatric populations unless specifically prescribed by a healthcare provider.

Administration:

• Intramuscular (IM): Inject directly into the muscle.

• Intravenous (IV): Inject slowly into the vein.

• Subcutaneous (SC): Inject into the subcutaneous tissue.

Note: Always follow the prescribed dosage and administration instructions from your healthcare provider.

Side Effects:

Like all medications, Hyoscine N Butylbromide (Hyozani) may cause side effects, though not everyone will experience them.

Common side effects include:

• Dry Mouth: A common side effect due to anticholinergic properties.

• Blurred Vision: Due to the drug's effect on the eye muscles, leading to difficulty focusing.

• Dizziness or Drowsiness: Some individuals may feel lightheaded or sleepy after injection.

• Constipation: Anticholinergic effects can slow down gastrointestinal motility.

• Skin Rash: In some cases, a rash may develop at the site of injection or elsewhere.

Less common but more serious side effects include:

• Tachycardia (increased heart rate): Due to the drug's anticholinergic effects on the heart.

• Urinary Retention: Difficulty urinating, particularly in individuals with underlying bladder problems.

• Confusion or Hallucinations: High doses or prolonged use may cause mental confusion, particularly in older adults.

• Severe Allergic Reactions: Swelling of the face, lips, tongue, or throat, which may cause difficulty breathing (anaphylaxis). This requires immediate medical attention.

If you experience any of the following, seek medical advice immediately:

• Severe abdominal pain or discomfort.

• Difficulty breathing or swallowing.

• Rapid or irregular heartbeat.

• Severe dizziness or loss of consciousness.

Contraindications:

Hyoscine N Butylbromide (Hyozani) should not be used in the following conditions:

• Hypersensitivity: If you have a known allergy to Hyoscine N Butylbromide or any other component of the medication.

• Narrow-Angle Glaucoma: This medication may increase intraocular pressure, which is contraindicated in patients with narrow-angle glaucoma.

• Myasthenia Gravis: This condition can be exacerbated by anticholinergic drugs like Hyoscine N Butylbromide, as it can worsen muscle weakness.

• Prostatic Hypertrophy: Men with enlarged prostates should avoid this medication due to the risk of urinary retention.

• Obstructive Bowel Disease: Individuals with a history of obstructive gastrointestinal conditions should avoid this drug.

• Severe Ulcerative Colitis: Hyoscine N Butylbromide can exacerbate certain gastrointestinal conditions, including ulcerative colitis.

Warnings and Precautions:

• Elderly Patients: Use with caution in elderly individuals, especially those with cardiovascular diseases or glaucoma. They may be more susceptible to the side effects of the medication, such as confusion, drowsiness, or urinary retention.

• Renal and Hepatic Impairment: If you have kidney or liver problems, your healthcare provider may adjust the dose or monitor you closely, as these organs play a role in the elimination of the medication.

• Pregnancy: Hyoscine N Butylbromide is classified as a Category C drug during pregnancy, meaning it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult with your healthcare provider before using this medication if you are pregnant.

• Breastfeeding: It is not known if Hyoscine N Butylbromide is excreted in breast milk, so caution is advised when using it while breastfeeding.

Drug Interactions:

• Anticholinergic Drugs: When used in combination with other anticholinergic drugs, the risk of anticholinergic side effects (e.g., dry mouth, constipation, urinary retention) is increased. Common examples include antihistamines, tricyclic antidepressants, and antipsychotics.

• Antihypertensive Medications: Hyoscine N Butylbromide can cause tachycardia (increased heart rate), potentially interfering with the effectiveness of medications used to control high blood pressure.

• CNS Depressants: The sedative effects of CNS depressants (e.g., benzodiazepines, opioids) can be enhanced when used in combination with Hyoscine N Butylbromide.

• Antacids: Some medications like antacids may reduce the absorption of the drug when taken together.

Pregnancy and Breastfeeding:

• Pregnancy: As mentioned, Hyoscine N Butylbromide should only be used during pregnancy if the potential benefits outweigh the risks. It is important to consult a healthcare provider before taking the medication while pregnant.

• Breastfeeding: Consult a healthcare provider before using Hyoscine N Butylbromide if you are breastfeeding, as the safety of this drug in breast milk has not been established.

Conclusion:

Hyoscine N Butylbromide (Hyozani) 20mg/ml Solution for Injection is a useful antispasmodic medication for the treatment of smooth muscle spasms, particularly in the gastrointestinal and genitourinary systems. It offers rapid relief for conditions like colic, abdominal cramps, and spasms. While generally safe, it should be used with caution in patients with certain conditions like glaucoma, prostatic hypertrophy, or intestinal obstruction. Always follow the prescribed dosage and consult a healthcare professional if you experience any unusual side effects or have concerns about interactions with other medications.