Metformin Hydrochloride (Saphormin T500) 500mg Film Coated Tablet 100's

Generic Name: Metformin Hydrochloride

Brand Name: Saphormin T500

Strength: 500mg

Form: Tablet

Manufacturer:

Imported and Distributed by:

Classification: Oral Hypoglycemic

Indication/Uses:

Metformin Hydrochloride (Saphormin T500) 500mg Film Coated Tablets are used primarily in the management of type 2 diabetes mellitus. Here are the indications and uses for this medication:

Indications and Uses

1. Type 2 Diabetes Mellitus:

   • Blood Glucose Control: Metformin is used to help control blood glucose levels in individuals with type 2 diabetes. It works by improving insulin sensitivity and decreasing hepatic glucose production.
   • First-Line Therapy: It is often the first medication prescribed for type 2 diabetes due to its efficacy and relatively low risk of causing hypoglycemia compared to other antidiabetic agents.

2. Insulin Sensitivity:

   • Improving Insulin Action: Metformin enhances the body’s ability to use insulin effectively, which helps in lowering blood sugar levels.

3. Weight Management:

   • Weight Neutrality: Metformin is associated with weight neutrality or modest weight loss, which can be beneficial for individuals with type 2 diabetes who are also managing weight.

4. Polycystic Ovary Syndrome (PCOS) (Off-label use):

   • Management: Metformin is sometimes used off-label to treat symptoms of PCOS, especially in cases where there is insulin resistance or impaired glucose tolerance.

Dosage and Administration

• Dosage: The usual starting dose for adults is 500 mg to 1000 mg taken two to three times daily with meals to reduce gastrointestinal side effects. The dose may be gradually increased based on blood glucose control and tolerance, up to a maximum of 2000 mg to 3000 mg per day, divided into two or three doses.
• Administration: Swallow the tablets whole with a glass of water. They should be taken with meals to help minimize gastrointestinal discomfort.

Precautions

• Renal Function: Use with caution in patients with renal impairment. Regular monitoring of kidney function is important, as metformin is contraindicated in severe renal dysfunction.
• Lactic Acidosis: Although rare, metformin can cause lactic acidosis, especially in patients with compromised renal function, liver disease, or severe infections. Symptoms include unusual fatigue, muscle pain, and difficulty breathing.
• Contrast Agents: Discontinue metformin temporarily if you need to undergo procedures that involve contrast agents, especially if there is a risk of renal impairment.

Side Effects

• Common: Gastrointestinal issues such as nausea, vomiting, diarrhea, and abdominal discomfort are common, particularly when starting treatment. These symptoms often diminish over time.
• Serious: Serious side effects are rare but can include lactic acidosis, severe allergic reactions, and vitamin B12 deficiency. Regular monitoring is necessary to detect and address these issues early.

Monitoring

• Blood Glucose Levels: Regular monitoring of blood glucose levels is essential to evaluate the effectiveness of the medication and adjust the dosage as needed.
• Kidney Function: Periodic assessment of renal function is recommended, particularly in patients with existing renal conditions or those experiencing symptoms that may indicate kidney issues.

Metformin Hydrochloride (Saphormin T500) 500mg Film Coated Tablets are used for managing type 2 diabetes by improving insulin sensitivity and controlling blood glucose levels. Proper dosage, adherence to guidelines, and regular monitoring are crucial for optimal management and to minimize potential side effects.