Bambang Pharmaceutical Depot Inc.
Metoclopramide Hydrochloride (Motillex) 10mg Tablet 100's
Metoclopramide Hydrochloride (Motillex) 10mg Tablet 100's
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Product Description:
Metoclopramide Hydrochloride (Motillex) 10mg tablets are a medication primarily used to treat various gastrointestinal disorders. It works by increasing the motility of the stomach and intestines, promoting faster emptying of the stomach contents into the small intestine. Motillex is classified as a prokinetic agent and antiemetic, making it useful in treating nausea, vomiting, and delayed gastric emptying. It also works as a dopamine antagonist, which helps in reducing nausea and improving digestive function.
Each tablet of Motillex contains 10mg of Metoclopramide Hydrochloride and is generally used to relieve symptoms of nausea, vomiting, and to aid in the treatment of certain gastric conditions.
Indications:
Metoclopramide (Motillex) 10mg tablets are indicated for the following conditions:
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Nausea and Vomiting:
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To treat nausea and vomiting caused by various conditions, such as those associated with chemotherapy, radiation therapy, or postoperative recovery.
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Gastroparesis:
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It is used to treat delayed gastric emptying (gastroparesis) in diabetic patients, improving gastric motility and helping in the digestion of food.
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GERD (Gastroesophageal Reflux Disease):
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Motillex can be used to relieve symptoms of GERD, such as heartburn, regurgitation, and chest pain, by improving the tone of the lower esophageal sphincter and speeding up stomach emptying.
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Postoperative Nausea and Vomiting:
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It can be used to prevent or treat nausea and vomiting following surgery, particularly for patients recovering from anesthesia.
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Morning Sickness in Pregnancy:
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In some cases, Motillex may be prescribed for the management of morning sickness during early pregnancy, though this should be done under strict medical supervision.
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Dosage:
The usual dosage for Metoclopramide (Motillex) 10mg tablets is as follows:
For Adults:
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Nausea and Vomiting (including chemotherapy-induced vomiting):
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Initial dose: 10mg up to 4 times per day. The dose is typically taken 30 minutes before meals and, if necessary, before sleep.
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Gastroparesis:
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The usual dose is 10mg taken 3 to 4 times a day, 30 minutes before meals.
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Gastroesophageal Reflux Disease (GERD):
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10mg taken 30 minutes before meals and at bedtime. This may vary depending on the severity of symptoms.
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Postoperative Nausea and Vomiting:
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10mg up to 3 times a day or as directed by a doctor.
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Morning Sickness in Pregnancy:
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Metoclopramide should only be prescribed during pregnancy if clearly needed. The typical dose would be 5-10mg, taken 2-3 times a day, under a healthcare provider's guidance.
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For Children:
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The dose for children is weight-based, and a doctor should determine the appropriate dosage. It is often lower than that for adults and should be administered under medical supervision.
Side Effects:
Common side effects of Metoclopramide (Motillex) 10mg tablets may include:
Common Side Effects:
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Drowsiness or fatigue.
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Diarrhea or loose stools.
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Restlessness or feeling nervous.
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Headache.
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Dizziness.
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Dry mouth.
Serious Side Effects:
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Extrapyramidal Symptoms (EPS): This includes symptoms like muscle stiffness, tremors, and abnormal movements (especially in the face or limbs). These symptoms can be seen in both children and adults, particularly with long-term or high-dose use.
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Tardive Dyskinesia: Long-term use of Metoclopramide may lead to tardive dyskinesia, a condition that causes involuntary movements, often in the face or tongue.
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Neuroleptic Malignant Syndrome (NMS): This is a rare but potentially life-threatening reaction involving symptoms like fever, muscle rigidity, altered mental status, and autonomic dysfunction (e.g., changes in blood pressure, heart rate).
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Severe allergic reactions: These may include symptoms such as swelling of the face, lips, tongue, or throat, and difficulty breathing, indicating an allergic reaction to the drug.
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Depression or mood changes: Rarely, the use of Metoclopramide may affect mood or lead to depression.
Contraindications:
Metoclopramide (Motillex) 10mg should be avoided in the following conditions:
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Hypersensitivity:
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Contraindicated in patients who are allergic to Metoclopramide or any of its components.
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Gastrointestinal Obstruction or Perforation:
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Should not be used in patients with mechanical gastrointestinal obstruction, perforation, or gastric hemorrhage, as it may worsen these conditions.
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Pheochromocytoma:
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Contraindicated in patients with pheochromocytoma, a rare tumor of the adrenal gland that can cause severe hypertension (high blood pressure).
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Severe Liver Disease:
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Contraindicated in individuals with severe liver dysfunction or hepatic failure.
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Epilepsy or Seizure Disorders:
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Metoclopramide may increase the risk of seizures, so it is contraindicated in individuals with a history of epilepsy or other seizure disorders.
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Parkinson's Disease:
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Patients with Parkinson's disease or other movement disorders should avoid Metoclopramide, as it can exacerbate extrapyramidal side effects like tremors, rigidity, or bradykinesia.
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Use in Newborns:
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Metoclopramide should not be used in neonates (newborns) due to the risk of severe adverse effects.
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Precautions:
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Pregnancy and Breastfeeding:
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Metoclopramide should be used during pregnancy only if absolutely necessary, as it crosses the placenta. It should also be used with caution in breastfeeding mothers, as it may pass into breast milk.
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Elderly Patients:
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Elderly patients may be more susceptible to adverse effects, particularly extrapyramidal symptoms and sedation. Close monitoring is advised.
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Monitor for Side Effects:
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Regular monitoring is recommended, especially for long-term users of Metoclopramide, to detect any development of tardive dyskinesia or extrapyramidal symptoms.
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Kidney Function:
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Metoclopramide should be used cautiously in patients with renal impairment, as kidney dysfunction can affect the drug's clearance.
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Driving and Operating Machinery:
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Since Motillex may cause drowsiness or dizziness, caution should be exercised when driving or operating heavy machinery.
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Drug Interactions:
Metoclopramide (Motillex) 10mg may interact with several drugs, including:
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Anticholinergics:
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Medications with anticholinergic effects (e.g., antihistamines, tricyclic antidepressants) may reduce the effectiveness of Metoclopramide by opposing its prokinetic actions.
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CNS Depressants:
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Concurrent use with other CNS depressants (e.g., alcohol, sedatives, tranquilizers) may enhance sedative effects and increase the risk of drowsiness.
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Dopaminergic Drugs:
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Metoclopramide may reduce the effectiveness of dopaminergic drugs, including those used for Parkinson's disease (e.g., levodopa), by antagonizing dopamine receptors.
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Cyclosporine:
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Metoclopramide may increase blood levels of cyclosporine, a medication used to prevent organ transplant rejection, potentially leading to toxicity.
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Digoxin:
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Metoclopramide may increase the absorption of digoxin, potentially increasing its blood levels and the risk of digoxin toxicity.
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Monoamine Oxidase Inhibitors (MAOIs):
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The use of Metoclopramide with MAO inhibitors (e.g., phenelzine) can increase the risk of serotonin syndrome, a potentially life-threatening condition.
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Conclusion:
Metoclopramide Hydrochloride (Motillex) 10mg tablets are effective for treating nausea, vomiting, and certain gastrointestinal conditions by improving motility and reducing symptoms of reflux. While effective, it should be used with caution, particularly in patients with a history of movement disorders, epilepsy, or severe liver or kidney disease. Always follow the prescribed dosage, and consult a healthcare provider for any concerns regarding side effects or drug interactions.
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