Nicardipine Hydrochloride (Nicarsaph) 1mg/ml Solution for IV Infusion 10 x Ampoules 1's

Generic Name: Nicardipine Hydrochloride

Brand Name: Nicarsaph

Strength: 1m / ml 

Form: Ampoule

Manufacturer:

Imported and Distributed by: 

Classification: Calcium Channel Blocker

Indication/Uses:

Nicardipine Hydrochloride (Nicarsaph) 1mg/ml Solution for IV Infusion (10 x 1ml Ampoules) is a calcium channel blocker used primarily for managing hypertension and certain other cardiovascular conditions. Here are the primary indications and uses:

Indications and Uses

1. Hypertension:

   • Acute Hypertension: Used for the management of severe hypertension, particularly in acute situations such as hypertensive emergencies or during surgery.
   • Chronic Hypertension: Sometimes used in a controlled intravenous setting to manage chronic hypertension when oral medications are not suitable.

2. Angina:

   • Angina Pectoris: Provides relief from angina (chest pain) due to coronary artery disease by dilating blood vessels and improving blood flow to the heart.

3. Preoperative and Postoperative Blood Pressure Control:

   • Blood Pressure Management: Used to control blood pressure during and after surgical procedures, especially when rapid and precise control is needed.

4. Management of Certain Cardiac Conditions:

   • Hypertensive Crisis: Useful in controlling blood pressure in patients experiencing a hypertensive crisis.

Mechanism of Action

• Calcium Channel Blocker: Nicardipine is a dihydropyridine calcium channel blocker that works by inhibiting the influx of calcium ions into cardiac and smooth muscle cells. This results in the relaxation of vascular smooth muscle and dilation of blood vessels, leading to a reduction in blood pressure and decreased workload on the heart.

Dosage and Administration

• Dosage: The dosage of nicardipine hydrochloride should be individualized based on the patient’s condition and response. The typical infusion rate is started at a low dose and adjusted as needed.
  • Initial Dose: Often starts with an infusion rate of 5 mg/hour.
  • Adjustment: The dose may be adjusted every 5 to 15 minutes based on the patient’s blood pressure response. The maximum dose is usually up to 15 mg/hour.
• Administration: Administered intravenously as a continuous infusion. The infusion rate should be carefully monitored and adjusted based on the patient’s response and blood pressure.

Instructions for Use

1. Preparation:

   • Inspect the ampoules for any particulate matter or discoloration before use.
   • Prepare the infusion using aseptic techniques. Dilute as required per manufacturer’s instructions or institutional protocols.

2. Administration:

   • Administer the solution using an infusion pump to ensure accurate dosing.
   • Monitor the patient’s blood pressure and heart rate regularly to adjust the infusion rate as needed.

3. Monitoring:

   • Continuous monitoring of blood pressure is essential to avoid hypotension or other adverse effects.
   • Monitor for any signs of adverse reactions or complications, such as dizziness, headache, or tachycardia.

Precautions

• Cardiovascular Monitoring: Monitor blood pressure and heart rate closely during administration to prevent excessive hypotension or bradycardia.
• Renal and Hepatic Function: Use with caution in patients with renal or hepatic impairment, as clearance may be reduced.
• Drug Interactions: Be cautious of potential interactions with other medications that can affect blood pressure or cardiac function.

Side Effects

• Common: Headache, flushing, hypotension, nausea, and dizziness.
• Serious: Severe hypotension, tachycardia, peripheral edema, or allergic reactions such as rash or swelling.

Storage

• Storage: Store the ampoules at room temperature, away from direct light and moisture. Follow specific storage instructions provided by the manufacturer.

Nicardipine Hydrochloride (Nicarsaph) 1mg/ml Solution for IV Infusion is a critical medication for managing acute and severe hypertension, angina, and other cardiovascular conditions requiring precise blood pressure control. Proper dosing, administration, and monitoring are essential to ensure its effectiveness and minimize potential side effects.