Omeprazole (Xoprazole Plus) 40mg Delayed Release Capsule 70's

Omeprazole (Xoprazole Plus) 40mg Delayed Release Capsule 70's

Product Description:

Xoprazole Plus 40mg contains Omeprazole, a proton pump inhibitor (PPI) that works by decreasing the amount of acid produced in the stomach. It is used to treat various stomach and esophagus-related conditions, including acid reflux and ulcers. The capsules are delayed-release, ensuring the medication is released gradually in the small intestine, which enhances its effectiveness. Each pack contains 70 capsules, with each capsule delivering 40mg of Omeprazole.

Indications:

Xoprazole Plus (Omeprazole) is used to treat the following conditions:

1. Gastroesophageal Reflux Disease (GERD):

   • Xoprazole is used to treat symptoms of GERD, which is a condition where stomach acid frequently flows back into the esophagus, causing heartburn and irritation.

2. Peptic Ulcers:

   • It is used in the treatment of gastric and duodenal ulcers to promote healing by reducing stomach acid production.

3. Helicobacter pylori Eradication:

   • Often used in combination with antibiotics to treat H. pylori infections, which are linked to the development of ulcers.

4. Zollinger-Ellison Syndrome:

   • This is a rare condition in which the stomach produces excessive acid, and Xoprazole Plus helps to control acid production.

5. Prevention of Stomach Ulcers:

   • It can be used to prevent the formation of ulcers in patients taking NSAIDs (Nonsteroidal Anti-Inflammatory Drugs).

Dosage and Administration:

For GERD and Peptic Ulcers:

• Adults: The typical dose is 20-40mg once daily before a meal for 4-8 weeks, depending on the severity of the condition.

For Helicobacter pylori Eradication (in combination with antibiotics):

• The usual dose is 40mg once daily for 10-14 days in combination with other antibiotics (usually clarithromycin and amoxicillin or metronidazole).

For Zollinger-Ellison Syndrome:

• Adults: The starting dose is usually 60mg once daily, but may be increased depending on the individual needs of the patient, sometimes up to 120mg per day, divided into 2 doses.

For Preventing NSAID-Induced Ulcers:

• Adults: The dose is typically 20mg once daily.

Side Effects:

Most people tolerate Xoprazole Plus well, but side effects can occur. Common side effects include:

Common Side Effects:

• Headache.

• Diarrhea.

• Nausea.

• Abdominal pain.

• Flatulence (gas).

• Dizziness.

Serious Side Effects (Rare):

• Severe allergic reactions: Symptoms may include difficulty breathing, swelling of the lips, tongue, or throat, and skin rash.

• Bone fractures: Long-term use may increase the risk of bone fractures, particularly in older adults or those with other risk factors.

• Kidney problems: Symptoms such as swelling of the feet or ankles, and decreased urination may indicate kidney problems.

• Low magnesium levels: Symptoms include muscle spasms, irregular heartbeat, or dizziness.

• Clostridium difficile-associated diarrhea: A potentially serious bacterial infection causing diarrhea.

Contraindications:

Xoprazole Plus (Omeprazole) should not be used in the following conditions:

1. Hypersensitivity:

   • Contraindicated in individuals who are allergic to Omeprazole or any of the other ingredients in the product.

2. Severe Hepatic Impairment:

   • In patients with severe liver disease (cirrhosis or liver failure), Xoprazole Plus should be used with caution, and the dosage may need to be adjusted. A lower dose or an alternative medication may be preferred.

3. Pregnancy and Breastfeeding:

   • While Xoprazole Plus is Category C for pregnancy, meaning it may cause harm to a fetus, it should only be used when necessary and under the supervision of a healthcare provider. It is excreted in breast milk, so breastfeeding mothers should consult their doctor before using this medication.

4. Co-administration with Certain Drugs:

   • Caution should be exercised when co-administering Omeprazole with Clopidogrel, as Omeprazole may reduce the effectiveness of Clopidogrel, a drug used to prevent heart attacks and strokes.

Precautions:

1. Long-term Use: Long-term use of Xoprazole Plus may lead to nutrient deficiencies, such as vitamin B12 deficiency, and an increased risk of bone fractures. Regular monitoring may be necessary.

2. H. Pylori Treatment: When used for H. pylori eradication, it should be used in combination with the appropriate antibiotics, and the full treatment regimen should be completed.

3. Liver Disease: For patients with mild to moderate liver dysfunction, the dosage may need to be reduced. Close monitoring is advised.

4. Renal Disease: For patients with renal impairment, the medication is generally considered safe, but caution is advised, and renal function should be monitored.

Overdose:

In case of overdose, symptoms may include:

• Nausea.

• Vomiting.

• Dizziness.

• Abdominal pain.

In the case of overdose, medical attention should be sought immediately. Treatment is usually symptomatic, and Xoprazole Plus can be dialyzed to remove the drug from the body.

Conclusion:

Xoprazole Plus 40mg is an effective treatment for reducing stomach acid production and managing conditions such as GERD, peptic ulcers, Zollinger-Ellison syndrome, and H. pylori infection. It is generally well-tolerated, though side effects such as headaches, nausea, or gastrointestinal disturbances can occur. Long-term use should be monitored for complications like nutrient deficiencies or bone fractures. It is important to consult with a healthcare provider before using this medication, particularly for patients with liver disease, pregnant or breastfeeding women, and individuals on certain other medications.