Classification: Non-Steroidal Anti Inflammatory Drug
Indication/Uses:
Piroxicam, marketed as Piroxisaph in 20mg capsules, is a nonsteroidal anti-inflammatory drug (NSAID) used to manage pain and inflammation. Here are the main indications and uses:
Indications and Uses
Osteoarthritis:
Pain and Inflammation: Used to relieve symptoms of osteoarthritis, such as pain, swelling, and stiffness in the joints.
Rheumatoid Arthritis:
Pain and Inflammation: Effective in reducing pain and inflammation associated with rheumatoid arthritis, a chronic autoimmune condition affecting the joints.
Acute Pain:
Short-term Pain Relief: Used for the management of acute pain conditions, such as postoperative pain or pain from injury.
Musculoskeletal Disorders:
Pain and Inflammation: Helps alleviate pain and inflammation in various musculoskeletal disorders, including strains and sprains.
Mechanism of Action
Inhibition of Cyclooxygenase (COX): Piroxicam works by inhibiting the activity of cyclooxygenase (COX) enzymes, which play a key role in the synthesis of prostaglandins. Prostaglandins are chemicals in the body that mediate inflammation, pain, and fever. By reducing prostaglandin levels, piroxicam helps decrease inflammation and relieve pain.
Dosage and Administration
Typical Dosage: The usual dose is 20mg once daily. The dosage may vary based on the condition being treated and the patient's response to the medication.
Administration: Capsules should be taken orally with a full glass of water, preferably with food or milk to minimize gastrointestinal irritation.
Precautions
Gastrointestinal Risk: Prolonged use may increase the risk of gastrointestinal ulcers, bleeding, or perforation. Patients with a history of gastrointestinal issues should use with caution.
Cardiovascular Risk: Use with caution in patients with a history of cardiovascular disease or hypertension, as NSAIDs can increase the risk of heart attack or stroke.
Renal Function: Monitor renal function, especially in patients with existing kidney conditions, as NSAIDs can affect kidney function.
Monitoring
Gastrointestinal Health: Monitor for signs of gastrointestinal bleeding or ulcers, particularly with long-term use.
Cardiovascular Health: Regularly check blood pressure and cardiovascular health, especially in patients with pre-existing conditions.
Renal Function: Assess kidney function periodically, particularly in patients with pre-existing renal conditions.
Piroxicam (Piroxisaph) is a potent NSAID used for managing pain and inflammation in various conditions. Proper use and monitoring are essential to minimize risks and achieve effective relief of symptoms.
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