Ranitidine Hydrochloride (Gastrosaph AF300) 300mg Film Coated Tablet 100's

Generic Name: Ranitidine Hydrochloride

Brand Name: Gastrosaph AF300

Strength: 300mg

Form: Tablet

Manufacturer:

Imported and Distributed by:

Classification: H2- Receptor Antagonist

Indication/Uses:

Ranitidine Hydrochloride (Gastrosaph AF300) 300mg Film-Coated Tablets are used for managing conditions related to excessive stomach acid. Here are the primary indications and uses for this medication:

Indications and Uses

1. Gastric Ulcers:

   • Treatment and Prevention: Used to treat active gastric ulcers and to help prevent their recurrence by reducing stomach acid production, which promotes healing of the ulcer.

2. Duodenal Ulcers:

   • Management: Effective in treating duodenal ulcers and preventing their recurrence by decreasing stomach acid secretion.

3. Gastroesophageal Reflux Disease (GERD):

   • Symptom Relief: Helps manage GERD symptoms by reducing acid reflux into the esophagus, which alleviates symptoms such as heartburn and regurgitation.

4. Zollinger-Ellison Syndrome:

   • Excess Acid Production: Used to manage Zollinger-Ellison syndrome, a condition characterized by excessive gastric acid production.

5. Preoperative Medication:

   • Acid Reduction: May be used before surgical procedures to reduce the risk of acid aspiration and related complications.

Mechanism of Action

• H2-Receptor Antagonism: Ranitidine is an H2 receptor antagonist that works by blocking histamine H2 receptors in the stomach lining. This action reduces the production of stomach acid, which helps to alleviate symptoms of acid-related conditions and promotes the healing of ulcers.

Dosage and Administration

• Typical Dosage:
  • Gastric and Duodenal Ulcers: The usual dose is 300mg once daily at bedtime or 150mg twice daily, depending on the severity and response to treatment.
  • GERD: Often, 300mg once daily at bedtime or 150mg twice daily is used to manage symptoms.
  • Zollinger-Ellison Syndrome: Higher doses may be required based on the severity of the condition and individual response.
• Administration: Tablets should be taken orally with or without food. Swallow the tablets whole; do not crush or chew.

Precautions

• Renal Impairment: Use with caution in patients with renal impairment, as dosage adjustments may be necessary.
• Allergies: Ensure there are no known allergies to ranitidine or other H2 receptor antagonists.
• Drug Interactions: Be aware of potential drug interactions, particularly with medications that are affected by changes in stomach pH or metabolism.

Side Effects

• Common: Headache, dizziness, gastrointestinal disturbances such as constipation or diarrhea.
• Serious: Rare but serious side effects may include allergic reactions, liver enzyme changes, and blood disorders such as thrombocytopenia or agranulocytosis.

Monitoring

• Regular Monitoring: Regular follow-ups may be necessary to monitor for potential side effects, especially with long-term or high-dose therapy.
• Renal Function: Regular checks of renal function may be required in patients with compromised kidney function or those on prolonged treatment.

Ranitidine Hydrochloride (Gastrosaph AF300) 300mg Film-Coated Tablets are used to manage various acid-related conditions, including ulcers and GERD. Adherence to dosing guidelines, proper administration, and monitoring are important for effective treatment and minimizing potential side effects.